| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ICAM2; Intercellular adhesion molecule 2; ICAM-2; CD102 |
| Entrez GeneID | 3384; |
| WB Predicted band size | 30kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human ICAM-2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ICAM-2抗体的模拟参考文献示例(文献及内容为假设性概括，供参考)：
1. **文献名称**：*ICAM-2 regulates T cell migration in inflammatory responses*
**作者**：Smith A, et al.
**摘要**：研究通过抗ICAM-2抗体阻断实验，揭示ICAM-2在T细胞跨内皮迁移中的关键作用，表明其通过调控细胞骨架重组促进炎症反应中的免疫细胞募集。
2. **文献名称**：*Structural mapping of ICAM-2 epitopes using monoclonal antibodies*
**作者**：Lee C, et al.
**摘要**：利用多种ICAM-2单克隆抗体进行表位定位，发现抗体结合区域集中于细胞外Ig样结构域，为开发靶向ICAM-2的免疫疗法提供结构基础。
3. **文献名称**：*ICAM-2 expression in tumor vasculature and antibody-mediated inhibition of metastasis*
**作者**：Garcia R, et al.
**摘要**：通过抗ICAM-2抗体检测肿瘤血管内皮表达，证明其高表达与转移相关;抗体干预可显著降低小鼠模型中肿瘤细胞的血行扩散。
4. **文献名称**：*Role of ICAM-2 in dendritic cell-T cell interactions*
**作者**：Wang Y, et al.
**摘要**：使用ICAM-2中和抗体研究树突状细胞与T细胞间黏附，发现ICAM-2缺失削弱免疫突触形成，影响抗原提递效率。
注：以上为模拟文献，实际研究需通过学术数据库(如PubMed)检索真实发表论文。
ICAM-2 (Intercellular Adhesion Molecule 2), also known as CD102. is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is constitutively expressed on endothelial cells, platelets, and certain immune cells, playing a critical role in cell-cell adhesion, leukocyte migration, and immune response regulation. Structurally, ICAM-2 contains two immunoglobulin-like domains and binds to the β2 integrin LFA-1 (lymphocyte function-associated antigen-1) on leukocytes, facilitating their adhesion and transendothelial migration during inflammation. Unlike ICAM-1. its expression is less responsive to inflammatory cytokines, suggesting distinct regulatory roles in homeostasis and immune surveillance.
Antibodies targeting ICAM-2 are widely used in research to study its function in vascular biology, immune disorders, and cancer. For example, ICAM-2 antibodies help elucidate its involvement in angiogenesis, platelet activation, and T-cell signaling. In disease contexts, altered ICAM-2 expression has been linked to atherosclerosis, autoimmune conditions, and tumor metastasis. Researchers employ these antibodies in techniques like flow cytometry, immunohistochemistry, and functional blocking assays to explore ICAM-2's interactions and pathways.
Despite its importance, ICAM-2's functional redundancy with other adhesion molecules and subtle regulatory mechanisms remain under investigation. Therapeutic targeting of ICAM-2 is less advanced compared to ICAM-1. but ongoing studies aim to exploit its role in modulating immune responses or vascular permeability for clinical applications.
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