| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | CT1.10; MAGE10 |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MAGEA10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于Integrin β4抗体的参考文献示例(注：以下内容为虚构示例，仅用于格式参考)：
1. **"Targeting Integrin β4 in Triple-Negative Breast Cancer"**
- Authors: Smith A, et al.
- 摘要：研究探讨Integrin β4抗体在抑制三阴性乳腺癌侵袭和转移中的作用，发现其通过阻断肿瘤细胞与基底膜黏附降低转移潜能。
2. **"Integrin β4 Antibody Modulates Tumor Microenvironment in Pancreatic Cancer"**
- Authors: Lee C, et al.
- 摘要：利用Integrin β4特异性抗体干预胰腺癌模型，揭示其在调节肿瘤基质相互作用和增强化疗敏感性中的机制。
3. **"Functional Role of Integrin β4 in Keratinocyte Migration"**
- Authors: Tanaka Y, et al.
- 摘要：通过抗体阻断实验，证明Integrin β4在表皮细胞迁移和伤口愈合中的关键功能，涉及PI3K/Akt信号通路调控。
4. **"Integrin β4 as a Biomarker in Colorectal Cancer Progression"**
- Authors: Rodriguez M, et al.
- 摘要：开发高特异性Integrin β4抗体用于结直肠癌组织检测，证实其表达水平与患者预后及血管生成相关。
建议通过PubMed或Google Scholar搜索真实文献，关键词：**"Integrin β4 antibody" + "cancer"/"signaling"/"therapy"**。
Integrin β4. a key subunit of the α6β4 integrin heterodimer, is a transmembrane receptor critical for cell-matrix adhesion and signaling. Unlike other integrins, β4 contains a uniquely long cytoplasmic domain with multiple signaling motifs, enabling it to interact with intermediate filaments via plectin and anchor epithelial cells to the basement membrane through hemidesmosomes. This structural specialization links mechanical stability to regulatory functions in cell migration, proliferation, and survival.
Antibodies targeting integrin β4 are essential tools for studying its role in physiological and pathological contexts. They are widely used in techniques like immunohistochemistry, flow cytometry, and Western blot to localize β4 expression, assess protein levels, or investigate interactions with ligands such as laminins. In cancer research, β4 antibodies help explore its dual role: while it supports epithelial integrity in normal tissues, β4 overexpression in carcinomas often correlates with enhanced tumor invasiveness and resistance to therapy via PI3K/Akt or MAPK pathway activation. Additionally, these antibodies aid in diagnosing blistering skin disorders (e.g., epidermolysis bullosa) caused by dysfunctional hemidesmosomes.
Research applications also include evaluating β4's crosstalk with growth factor receptors (e.g., EGFR, HER2) and its potential as a therapeutic target. However, antibody specificity must be validated due to structural similarities among integrin subunits. Overall, integrin β4 antibodies remain pivotal in dissecting cell adhesion mechanisms and their implications in disease progression.
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