| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/10000 | Human,Mouse,Rat Monkey |
| Aliases | TGFB3; Transforming growth factor beta-3; TGF-beta-3 |
| Entrez GeneID | 7043; |
| WB Predicted band size | 13kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from the Internal region of human TGFβ3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于TGFβ3抗体的模拟参考文献示例(仅供参考，非真实文献)：
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1. **文献名称**: *"Role of TGFβ3 in Cardiac Fibrosis: Insights from Antibody-Based Inhibition Studies*
**作者**: Smith A, et al.
**摘要**: 本研究通过使用TGFβ3特异性抗体(克隆X)阻断其活性，发现TGFβ3在心肌纤维化中通过激活Smad2/3通路促进成纤维细胞分化。Western blot和免疫组化证实抗体可有效抑制TGFβ3信号。
2. **文献名称**: *"TGFβ3 Antibody Localization in Embryonic Skin Development*
**作者**: Lee C, et al.
**摘要**: 利用兔源多克隆TGFβ3抗体进行免疫荧光染色，揭示TGFβ3在小鼠胚胎表皮形态发生中的时空表达模式，表明其参与上皮-间质转化(EMT)调控。
3. **文献名称**: *"Validation of a Novel TGFβ3 Neutralizing Antibody for In Vivo Applications*
**作者**: Zhang Y, et al.
**摘要**: 报道一种高亲和力人源化TGFβ3单抗(mAb-7C2)，可在小鼠模型中抑制肿瘤微环境中的基质重塑，并通过ELISA和流式细胞术验证其特异性。
4. **文献名称**: *"TGFβ3-Specific Antibody Attenuates Pulmonary Fibrosis in a Rat Model*
**作者**: Gupta R, et al.
**摘要**: 使用TGFβ3中和抗体(克隆D11)治疗博来霉素诱导的肺纤维化大鼠，结果显示胶原沉积减少，提示靶向TGFβ3可能为纤维化疾病提供新疗法。
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**建议**：实际文献请通过PubMed、Google Scholar等平台检索，关键词：
`"TGFβ3 antibody" + application`(如immunohistochemistry, neutralization, fibrosis等)。
推荐筛选近5年高被引论文或权威期刊(如*Nature Communications*, *Journal of Biological Chemistry*)。
The TGFβ3 antibody is a crucial tool for studying transforming growth factor beta 3 (TGFβ3), a multifunctional cytokine belonging to the TGF-β superfamily. TGFβ3 plays pivotal roles in regulating cell proliferation, differentiation, apoptosis, and immune responses, with specific involvement in embryonic development, tissue repair, and immune modulation. Unlike TGFβ1 and TGFβ2. TGFβ3 is particularly associated with mediating epithelial-mesenchymal transitions (EMT) during palate formation and wound healing, making it a key target in developmental biology and fibrosis research.
Antibodies against TGFβ3 are designed to detect and quantify this protein in various experimental settings, including Western blotting (WB), immunohistochemistry (IHC), and enzyme-linked immunosorbent assays (ELISA). Both monoclonal and polyclonal variants are available, with specificity validated through knockout controls or neutralizing assays. These antibodies enable researchers to explore TGFβ3's dual role in health and disease, such as its tumor-suppressive functions versus its pro-metastatic effects in cancer, or its contribution to pathological fibrosis in organs like the liver and lungs.
Commercial TGFβ3 antibodies are widely used in studying conditions like Marfan syndrome, scarring disorders, and autoimmune diseases. Their applications extend to therapeutic development, including anti-fibrotic drugs and targeted cancer therapies. Proper validation remains critical due to potential cross-reactivity with other TGF-β isoforms. Suppliers such as R&D Systems, Abcam, and Santa Cruz Biotechnology provide research-grade antibodies, often with species reactivity spanning humans, mice, and rats.
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