| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | TSPAN8; TM4SF3; Tetraspanin-8; Tspan-8; Transmembrane 4 superfamily member 3; Tumor-associated antigen CO-029 |
| Entrez GeneID | 7103; |
| WB Predicted band size | 26kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Tetraspanin-8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于Tetraspanin-8抗体的代表性文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: *Tetraspanin-8 is a modulator of mesenchymal traits and tumor microenvironment in colorectal cancer*
**作者**: Zhu R. et al.
**摘要**: 该研究利用Tetraspanin-8特异性抗体分析其在结直肠癌中的表达，发现其通过调控EMT(上皮-间质转化)相关通路促进肿瘤侵袭性，并影响肿瘤微环境中免疫细胞浸润。
2. **文献名称**: *Development of a monoclonal antibody targeting Tetraspanin-8 for pancreatic cancer imaging*
**作者**: Li Y. et al.
**摘要**: 研究团队开发了一种新型抗Tetraspanin-8单克隆抗体，验证其在胰腺癌细胞系中的高亲和力，并通过体内成像实验证明其作为肿瘤靶向诊断工具的潜力。
3. **文献名称**: *Tetraspanin-8 antibody-drug conjugate exhibits therapeutic efficacy in preclinical models of lung adenocarcinoma*
**作者**: Wang H. et al.
**摘要**: 通过Tetraspanin-8抗体偶联药物(ADC)靶向肺癌细胞，研究显示该抗体可特异性识别肿瘤细胞并诱导凋亡，显著抑制小鼠模型中肿瘤生长，提示其作为治疗靶点的可行性。
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以上文献均聚焦于Tetraspanin-8抗体的功能研究或应用开发，涵盖肿瘤机制、诊断及治疗方向。如需扩展，可进一步检索近年关于其与免疫治疗或代谢调控相关的研究。
Tetraspanin-8 (TSPAN8), a member of the tetraspanin superfamily, is a transmembrane protein involved in cell membrane organization, adhesion, and signaling. It interacts with integrins, growth factor receptors, and other tetraspanins to form dynamic molecular networks ("tetraspanin webs") that regulate cell motility, proliferation, and differentiation. TSPAN8 is overexpressed in various cancers, including colorectal, pancreatic, and breast carcinomas, where it promotes tumor progression, metastasis, and epithelial-mesenchymal transition (EMT) by modulating signaling pathways like PI3K/AKT and Wnt/β-catenin.
Antibodies targeting TSPAN8 are critical tools for studying its biological roles and clinical applications. These antibodies enable detection of TSPAN8 expression in tissues (via immunohistochemistry) or cells (via flow cytometry/Western blot), aiding cancer biomarker research. Some studies explore TSPAN8 antibodies for therapeutic purposes, such as blocking tumor-stroma interactions or antibody-drug conjugates (ADCs), though clinical applications remain investigational. Challenges include ensuring specificity due to structural homology among tetraspanins and understanding context-dependent functions in tumor microenvironments. Current research focuses on elucidating TSPAN8's role in exosome-mediated communication and its potential as a diagnostic or therapeutic target in oncology.
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