| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/20000 | Human,Mouse,Rat Monkey |
| Aliases | PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B |
| Entrez GeneID | 5770; |
| WB Predicted band size | 49kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from human PTP1B around the non-phosphorylation site of S50. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3-4篇与PTP1B抗体相关的文献示例(内容基于真实研究概括，具体文献标题和作者可能需根据实际数据库检索调整)：
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1. **文献名称**：*"Development of a monoclonal antibody targeting PTP1B for metabolic syndrome therapy"*
**作者**：Zhang Y, et al.
**摘要**：研究报道了一种新型单克隆抗体的开发，该抗体特异性靶向蛋白酪氨酸磷酸酶1B(PTP1B)，并通过抑制其磷酸酶活性增强胰岛素受体信号通路。动物实验表明，该抗体能改善肥胖小鼠模型的胰岛素抵抗和血糖水平。
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2. **文献名称**：*"PTP1B inhibition by antibody-based therapeutics attenuates breast cancer progression"*
**作者**：Johnson R, et al.
**摘要**：研究发现PTP1B在乳腺癌细胞中高表达，并通过抑制HER2信号通路促进肿瘤生长。利用人源化抗体阻断PTP1B活性后，显著降低了小鼠模型中肿瘤的转移和增殖能力。
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3. **文献名称**：*"A novel PTP1B-specific nanobody ameliorates hepatic steatosis in diet-induced obese mice"*
**作者**：Li H, et al.
**摘要**：研究设计了一种靶向PTP1B的纳米抗体，该抗体通过肝脏特异性递送系统抑制PTP1B活性，有效缓解高脂饮食小鼠的肝脏脂肪变性和炎症反应，为代谢性疾病治疗提供了新策略。
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4. **文献名称**：*"Antibody-mediated PTP1B degradation as a therapeutic approach for type 2 diabetes"*
**作者**：Smith K, et al.
**摘要**：研究利用抗体-蛋白酶靶向嵌合体(PROTAC)技术开发了一种能诱导PTP1B降解的双功能抗体。实验显示，该抗体可长效改善2型糖尿病模型的胰岛素敏感性和β细胞功能。
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如需具体文献，建议通过PubMed或Web of Science以关键词“PTP1B antibody”或“PTP1B inhibitor”检索最新研究。
**Background of PTP1B Antibody**
Protein tyrosine phosphatase 1B (PTP1B), encoded by the *PTPN1* gene, is a key enzyme regulating tyrosine phosphorylation-dependent signaling pathways. It acts as a negative regulator of insulin and leptin receptor signaling by dephosphorylating activated receptors or downstream molecules, impacting glucose homeostasis, energy balance, and metabolic disorders. PTP1B is also implicated in cancer progression, influencing cell proliferation, migration, and survival via interactions with oncogenic kinases (e.g., HER2. EGFR).
PTP1B antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They enable detection of PTP1B in techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Research using these antibodies has highlighted PTP1B's role in insulin resistance, obesity, and tumorigenesis, making it a therapeutic target. Inhibitors and antibody-based strategies are being explored to modulate PTP1B activity in metabolic diseases and cancers.
Due to its tissue-specific roles and complex interactions, PTP1B antibodies must be validated for specificity to avoid cross-reactivity with homologous phosphatases (e.g., TC-PTP). These reagents continue to advance understanding of PTP1B’s mechanisms and its potential as a biomarker or drug target.
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