| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | SLC27A5; ACSB; ACSVL6; FACVL3; FATP5; Bile acyl-CoA synthetase; BACS; Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase; very long-chain 3; Solute carrier fam |
| Entrez GeneID | 10998; |
| WB Predicted band size | 75kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human ACSVL6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ACSVL6抗体的3篇代表性文献的简要信息(内容基于公开研究归纳，非真实文献)：
1. **文献名称**：*ACSVL6 as a Novel Biomarker in Triple-Negative Breast Cancer: Antibody Validation and Functional Analysis*
**作者**：Li Y, et al.
**摘要**：该研究开发并验证了一种特异性ACSVL6抗体，证实其在三阴性乳腺癌组织中高表达，并通过敲低实验证明ACSVL6通过调节脂肪酸代谢促进肿瘤侵袭。
2. **文献名称**：*Role of ACSVL6 in Hepatic Steatosis: Insights from Antibody-Based Protein Localization*
**作者**：Zhang H, et al.
**摘要**：利用ACSVL6特异性抗体进行免疫组化分析，发现其在非酒精性脂肪肝患者的肝细胞中表达显著上调，提示其参与脂质蓄积的分子机制。
3. **文献名称**：*Development of a Monoclonal Antibody for ACSVL6 and Its Application in Neurodegenerative Disease Models*
**作者**：Tanaka K, et al.
**摘要**：研究报道了一种高灵敏度抗ACSVL6单克隆抗体的开发，并发现阿尔茨海默病小鼠模型中ACSVL6蛋白水平异常，可能与神经元脂代谢紊乱相关。
注：以上文献为示例性质，实际研究中建议通过PubMed或Google Scholar以“ACSVL6 antibody”或“FACVL6”(别名)为关键词检索真实文献。
The ACSVL6 antibody targets the acyl-CoA synthetase very long-chain family member 6 (ACSVL6), a key enzyme involved in lipid metabolism. ACSVL6. also known as SLC27A6. belongs to the solute carrier family 27 (fatty acid transporters) and plays a role in activating very long-chain fatty acids (VLCFAs) by catalyzing their conversion to acyl-CoA derivatives. This process is critical for fatty acid degradation, membrane synthesis, and energy production. ACSVL6 is predominantly expressed in tissues with high metabolic demands, such as the liver, brain, and adipose tissue, suggesting its importance in systemic lipid homeostasis.
Research on ACSVL6 has gained attention due to its potential links to metabolic disorders, neurodegenerative diseases, and cancer. Dysregulation of ACSVL6 may contribute to abnormal lipid accumulation, insulin resistance, or impaired neuronal function. Antibodies against ACSVL6 are essential tools for studying its expression patterns, subcellular localization, and interactions in experimental models. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated ACSVL6 antibodies help clarify its tissue-specific roles, regulatory mechanisms, and therapeutic relevance in lipid-related pathologies. Recent studies also explore its involvement in ferroptosis, a lipid peroxidation-driven cell death pathway, highlighting its broader implications in disease mechanisms and treatment strategies.
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