| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RHR; B1AR; ADRB1R; BETA1AR |
| Entrez GeneID | 153; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human Beta-1 adrenergic receptor |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ADRB1抗体的参考文献示例(内容基于学术研究常见主题，非真实文献)：
1. **文献名称**：*"Autoantibodies Targeting β1-Adrenergic Receptor in Chronic Heart Failure: Pathogenic and Prognostic Implications"*
**作者**：Jahns R, Boivin V, Lohse MJ
**摘要**：探讨慢性心力衰竭患者体内抗ADRB1自身抗体的存在，发现其通过持续激活受体导致心肌细胞凋亡和功能恶化，并与不良预后相关。
2. **文献名称**：*"Development of a High-Affinity Monoclonal Antibody for β1-Adrenergic Receptor Localization Studies"*
**作者**：Limas CJ, Limas C
**摘要**：报道一种特异性单克隆抗体的生成，用于ADRB1的免疫组化和Western blot检测，验证其在心脏组织中的表达模式及疾病中的异常分布。
3. **文献名称**：*"β1-Adrenergic Receptor Autoantibodies in Autoimmune Cardiomyopathy: Mechanisms of Signal Interference"*
**作者**：Staudt A, Schlippert D, Escher F
**摘要**：揭示ADRB1自身抗体通过阻断受体与配体结合或激活异常信号通路，导致心肌收缩功能障碍，促进自身免疫性心肌病进展。
4. **文献名称**：*"Circulating β1-Adrenergic Receptor Antibodies in Essential Hypertension: Correlation with Sympathetic Activity"*
**作者**：Fu ML, Herlitz H, Wallukat G
**摘要**：分析高血压患者血清中ADRB1抗体的水平，发现其与交感神经活性增强相关，提示抗体可能通过增强受体敏感性参与血压调控异常。
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*注：以上文献为示例，实际引用时需核实真实来源及准确性。*
The β1-adrenergic receptor (ADRB1) is a G protein-coupled receptor (GPCR) predominantly expressed in the heart, kidneys, and adipose tissue. It mediates physiological responses to catecholamines like epinephrine and norepinephrine, regulating heart rate, cardiac contractility, and renin secretion via cAMP signaling. ADRB1 antibodies are essential tools for studying its expression, localization, and function in normal and pathological states. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to investigate ADRB1's role in cardiovascular diseases (e.g., heart failure, hypertension), metabolic disorders, and β-blocker drug mechanisms.
ADRB1 genetic polymorphisms (e.g., Arg389Gly) influence receptor activity and drug responses, making specific antibodies critical for personalized medicine research. Antibodies targeting distinct epitopes (e.g., extracellular or intracellular domains) help dissect receptor activation, internalization, and signaling pathways. Commercially available ADRB1 antibodies are typically raised in rabbits or mice, validated for species cross-reactivity (human, rat, mouse).
Research using ADRB1 antibodies has advanced understanding of its dysregulation in diseases and its potential as a therapeutic target. However, variability in antibody specificity necessitates rigorous validation to avoid off-target effects. Overall, ADRB1 antibodies remain pivotal in cardiovascular pharmacology and translational research.
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