| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ACN; ACINUS; fSAP152 |
| Entrez GeneID | 22985; |
| WB Predicted band size | 152kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human apoptotic chromatin condensation inducer 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ACIN1抗体的3篇参考文献示例(部分信息为假设性概括，仅供参考)：
1. **文献名称**：*"ACIN1 is a key factor for apoptotic chromatin condensation and caspase-3-mediated processing"*
**作者**：Sahara et al.
**摘要**：研究通过ACIN1特异性抗体证实其在HeLa细胞凋亡过程中被caspase-3切割，并调控染色质凝聚，揭示了其在凋亡信号通路中的核心作用。
2. **文献名称**：*"ACIN1 interacts with spliceosome components and regulates alternative splicing"*
**作者**：Oberst et al.
**摘要**：利用ACIN1抗体进行免疫共沉淀实验，发现ACIN1与剪接体蛋白(如SF3b)相互作用，表明其可能通过调控RNA剪接参与细胞稳态维持。
3. **文献名称**：*"Phosphorylation-dependent regulation of ACIN1 in DNA damage response"*
**作者**：Villunger et al.
**摘要**：通过Western blot和免疫荧光(使用ACIN1抗体)，揭示了DNA损伤后ACIN1的磷酸化修饰对其核定位及促凋亡功能的影响。
4. **文献名称**：*"ACIN1 nuclear localization signal and its role in neuronal development"*
**作者**：Shibata et al.
**摘要**：利用ACIN1抗体进行亚细胞定位分析，发现其核定位信号(NLS)对神经元分化至关重要，缺失该信号导致发育异常。
**注**：以上为基于ACIN1已知功能的模拟文献，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词“ACIN1 antibody”、“ACIN1 function”或结合具体研究领域(如凋亡、RNA剪接)进行精准查询。
The ACIN1 (Apoptotic Chromatin Condensation Inducer 1) antibody is a tool used to detect ACIN1. a multifunctional protein involved in apoptosis and RNA splicing. ACIN1. also known as ACINUS, contains distinct structural domains, including an N-terminal proline-rich region and an RS domain, which facilitate interactions with other proteins and RNA. In apoptosis, ACIN1 contributes to chromatin condensation and DNA fragmentation by interacting with apoptotic factors like Apoptosis-Inducing Factor (AIF). Simultaneously, it plays a role in pre-mRNA splicing as part of the spliceosome complex, associating with splicing regulators such as SRSF1.
ACIN1 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study its localization, expression levels, and molecular interactions. Research has linked ACIN1 dysregulation to diseases, including cancer and neurodegenerative disorders, where altered splicing or apoptotic pathways are implicated. For example, reduced ACIN1 expression has been observed in certain cancers, suggesting a tumor-suppressive role. These antibodies help dissect ACIN1's dual functions, providing insights into its context-dependent roles in cell survival, gene expression, and disease mechanisms. Ongoing studies aim to clarify its regulatory networks and therapeutic potential.
×
