| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LPHC; LPNC; MGB2; UGB3 |
| Entrez GeneID | 4246; |
| WB Predicted band size | 11kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human secretoglobin, family 2A, member 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SCGB2A1抗体的3篇参考文献的简要概述：
1. **文献名称**：SCGB2A1 as a prognostic biomarker in breast cancer: Expression analysis by immunohistochemistry
**作者**：Smith A, et al.
**摘要**：该研究通过免疫组化(IHC)检测SCGB2A1蛋白在乳腺癌组织中的表达，发现其高表达与患者预后不良相关，提示SCGB2A1可能作为乳腺癌的新型生物标志物。
2. **文献名称**：Expression profiling of SCGB2A1 in gastric cancer and its association with tumor progression
**作者**：Zhang L, et al.
**摘要**：作者利用SCGB2A1抗体进行Western blot和免疫组化分析，发现SCGB2A1在胃癌组织中显著上调，且与肿瘤侵袭、转移及患者生存期缩短密切相关。
3. **文献名称**：SCGB2A1 as a potential diagnostic marker for salivary gland tumors: A comparative study
**作者**：Johnson R, et al.
**摘要**：研究比较了SCGB2A1抗体在多型性腺瘤和腺样囊性癌中的表达差异，发现其在恶性唾液腺肿瘤中特异性高表达，可能辅助临床病理诊断。
4. **文献名称**：Localization of SCGB2A1 in lung adenocarcinoma using immunofluorescence
**作者**：Lee H, et al.
**摘要**：通过免疫荧光技术结合SCGB2A1抗体，研究发现该蛋白在肺腺癌细胞的胞质中特异性富集，可能与肿瘤微环境调控及化疗耐药性有关。
(注：上述文献信息为示例性内容，实际引用需根据具体论文调整。)
Secretoglobin family 2A member 1 (SCGB2A1), also known as mammaglobin B, is a small secreted protein belonging to the secretoglobin superfamily. It is predominantly expressed in hormone-responsive epithelial tissues, including mammary glands, salivary glands, and the endometrium. Structurally, SCGB2A1 forms disulfide-linked heterodimers with SCGB1D2 (lipophilin B), which stabilize its secretion and biological activity. While its precise physiological role remains unclear, SCGB2A1 is hypothesized to participate in immune modulation, inflammation regulation, and cellular differentiation within mucosal surfaces.
SCGB2A1 has gained attention as a tumor-associated antigen due to its overexpression in certain malignancies, particularly breast cancer and endometrial adenocarcinoma. Its restricted expression in normal tissues and high prevalence in tumors make it a potential biomarker for cancer detection and monitoring. Antibodies targeting SCGB2A1 are widely used in immunohistochemistry (IHC) and immunoassays to study protein localization, assess tumor progression, and differentiate primary tumor origins in metastatic settings. In diagnostic pathology, SCGB2A1 antibodies help distinguish breast carcinoma metastases from other malignancies. Recent research also explores its utility in developing targeted therapies and vaccines, leveraging its immunogenic properties. However, cross-reactivity with homologous family members requires careful antibody validation to ensure specificity in experimental and clinical applications.
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