| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e |
| Entrez GeneID | 18091 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This mouse Nkx2-5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 192-235 amino acids from the Central region of mouse Nkx2-5. |
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以下是关于SCARF2抗体的3篇参考文献的示例(注：部分内容为假设性描述，实际文献可能需要进一步检索验证)：
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1. **文献名称**：*Scavenger receptor class F member 2 (SCARF2) in endothelial cell function: Development of a polyclonal antibody for vascular studies*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种兔源多克隆抗体，用于检测SCARF2在内皮细胞中的表达。通过免疫组化和Western blot验证，发现SCARF2在血管生成过程中调控细胞迁移和黏附。
2. **文献名称**：*Monoclonal antibody targeting SCARF2 inhibits oxidized LDL uptake in macrophages*
**作者**：Yamamoto K, et al.
**摘要**：研究者制备了小鼠抗人SCARF2的单克隆抗体，证明其可特异性阻断巨噬细胞对氧化低密度脂蛋白(oxLDL)的摄取，提示SCARF2在动脉粥样硬化中的潜在作用。
3. **文献名称**：*SCARF2 antibody-based profiling reveals tissue-specific expression patterns in developmental disorders*
**作者**：Chen L, et al.
**摘要**：通过定制SCARF2抗体对Van den Ende-Gupta综合征患者组织样本进行分析，发现SCARF2在胚胎发育中的表达异常与结缔组织缺陷相关。
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**备注**：上述文献为示例，实际研究中可能需要通过PubMed或Google Scholar等平台检索真实存在的文献(如输入关键词“SCARF2 antibody”、“SCARF2 immunohistochemistry”等)。若需具体文献，建议访问学术数据库进一步筛选。
The SCARF2 (Scavenger Receptor Class F Member 2) antibody is a tool used to study the SCARF2 protein, a member of the scavenger receptor family. SCARF2 is a transmembrane glycoprotein implicated in cellular adhesion, lipid metabolism, and innate immunity. Structurally, it contains conserved domains typical of scavenger receptors, such as EGF-like and cysteine-rich regions, which facilitate ligand binding and receptor dimerization. SCARF2 interacts with modified lipoproteins and pathogen-associated molecules, suggesting roles in immune surveillance and clearance of cellular debris.
Research links SCARF2 to Van Den Ende-Gupta syndrome, a rare genetic disorder characterized by skeletal and connective tissue abnormalities, caused by mutations in the SCARF2 gene. It is also studied in cancer due to its altered expression in tumor microenvironments, potentially influencing cell migration and angiogenesis.
SCARF2 antibodies are essential for detecting protein expression via techniques like Western blotting, immunohistochemistry, and flow cytometry. Their specificity is validated using knockout controls or siRNA-based silencing. Commercial antibodies vary in host species (e.g., rabbit, mouse) and epitope targets, requiring careful selection based on experimental needs. Recent studies emphasize SCARF2's regulatory crosstalk with signaling pathways like Wnt/β-catenin, highlighting its broader biological relevance.
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