| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Septin-6; SEPT6; |
| Entrez GeneID | 23157; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SEPT6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SEPT6抗体的3篇参考文献示例(注：文献信息为模拟，仅供参考)：
1. **文献名称**：**"SEPT6 interacts with MLL fusion proteins and contributes to leukemogenesis"**
**作者**：Onishi M, Kinoshita S, Morikawa Y
**摘要**：该研究利用SEPT6抗体通过免疫共沉淀和免疫荧光技术，揭示了SEPT6与MLL融合蛋白的相互作用，并证明其在白血病细胞异常增殖中的调控作用。
2. **文献名称**：**"Septin 6 is required for the structural integrity of neuronal synapses"**
**作者**：Ihara M, Tomimoto H, Kitayama H
**摘要**：通过SEPT6抗体的免疫组化分析，研究发现SEPT6在小鼠大脑神经元突触中富集，并参与突触囊泡运输及突触稳定性的维持。
3. **文献名称**：**"Characterization of septin complexes in mammalian cells using specific antibodies"**
**作者**：Kinoshita M, Field CM, Mitchison TJ
**摘要**：该研究开发了针对SEPT6的特异性抗体，结合免疫印迹和质谱技术，解析了SEPT6与其他septin蛋白(如SEPT2/SEPT7)形成的异源复合物及其在胞质分裂中的功能。
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**备注**：以上文献为示例性质，实际引用时需核实真实文献信息。建议通过PubMed或Google Scholar以“SEPT6 antibody”及相关关键词检索最新研究。
SEPT6 (Septin 6) is a member of the septin family, a group of GTP-binding proteins involved in diverse cellular processes, including cytokinesis, cytoskeletal organization, and membrane dynamics. SEPT6 forms heteromeric complexes with other septins (e.g., SEPT2. SEPT7. SEPT9) to create filamentous structures that regulate cell division, vesicle trafficking, and cell polarity. It contains conserved GTPase and polybasic domains critical for its function.
SEPT6 is implicated in neurological disorders and cancers. For instance, chromosomal translocations involving SEPT6 and the MLL (mixed-lineage leukemia) gene are linked to acute myeloid leukemia (AML). In neurons, SEPT6 interacts with synaptic proteins, influencing synaptic plasticity and potentially contributing to neurodegenerative conditions like Alzheimer’s disease.
Antibodies targeting SEPT6 are essential tools for studying its expression, localization, and interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to explore SEPT6’s role in health and disease. Commercially available SEPT6 antibodies (monoclonal or polyclonal) are often validated for specificity using knockout controls or siRNA knockdown. Researchers utilize these antibodies to investigate SEPT6’s involvement in cancer progression, neuronal development, and its regulatory mechanisms in cellular dynamics. Reliable detection of SEPT6 aids in understanding its contributions to pathological pathways and potential therapeutic targets.
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