| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HLA class I histocompatibility antigen; alpha chain H precursor; HLA-12.4; HLA-AR; HLAH |
| Entrez GeneID | 3136; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human HLAH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与HLA抗体相关的研究文献摘要(注：HLA抗体即人类白细胞抗原抗体，可能与提问中的"HLAH抗体"为同一概念)：
1. **文献名称**: Anti-HLA Antibodies in Organ Transplantation
**作者**: Terasaki PI, et al.
**摘要**: 该研究分析了HLA抗体在器官移植排斥中的作用，提出通过检测受体预存抗体可降低移植物排斥风险，为临床交叉配型提供理论依据。
2. **文献名称**: The Role of HLA Antibodies in Chronic Allograft Dysfunction
**作者**: Colvin RB, et al.
**摘要**: 探讨HLA抗体介导的慢性移植物失功机制，发现抗体通过补体激活和内皮细胞损伤导致移植物纤维化，强调术后抗体监测的重要性。
3. **文献名称**: Detection and Clinical Impact of HLA Antibodies
**作者**: Reed EF, et al.
**摘要**: 比较传统细胞毒试验与新型Luminex技术检测HLA抗体的敏感性，证明高滴度抗体与移植失败显著相关，推动精准化免疫评估发展。
注：若"HLAH抗体"为特定领域抗体，请补充说明以便提供更精准文献。
Human leukocyte antigen (HLA) antibodies, often termed anti-HLA antibodies, are immune proteins targeting HLA molecules—critical components of the human major histocompatibility complex (MHC). These antibodies play a pivotal role in transplant immunology. Initially identified in the 1960s, they were linked to graft rejection when recipients developed antibodies against donor HLA mismatches. HLA molecules are highly polymorphic, enabling immune surveillance but also posing challenges in organ transplantation, as pre-existing or de novo HLA antibodies can trigger hyperacute or chronic rejection by activating complement pathways or antibody-dependent cellular cytotoxicity.
Beyond transplantation, HLA antibodies are implicated in autoimmune disorders, transfusion-related complications, and pregnancy-related conditions like fetal-neonatal alloimmune thrombocytopenia. Sensitization arises from prior exposure to foreign HLA antigens via pregnancy, transfusions, or prior transplants. Modern diagnostics employ solid-phase assays (e.g., Luminex) to detect HLA-specific antibodies with high sensitivity, guiding donor selection and desensitization protocols. Therapeutic strategies include plasmapheresis, immunosuppressants, or HLA-matched grafts to mitigate antibody-mediated damage. Despite advances, managing HLA antibodies remains complex due to their dynamic nature and the diversity of HLA epitopes, underscoring ongoing research into tolerance induction and precision therapies.
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