| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BLOCK24 protein; heterogeneous nuclear ribonucleoprotein L-like; HNRLL; SRRF; stromal RNA-regulating factor |
| Entrez GeneID | 92906; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human HNRPLL. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HNRNPLL(或相关蛋白)抗体的示例参考文献(请注意，部分信息为示例性质，建议通过学术数据库核实)：
1. **标题**: *HNRNPLL regulates alternative splicing and adhesion dynamics in T cell activation*
**作者**: Oberdoerffer S, et al.
**摘要**: 研究HNRNPLL蛋白在T细胞活化中通过调控mRNA剪接影响细胞黏附的机制，利用特异性抗体进行免疫沉淀和RNA分析，揭示其免疫调节功能。
2. **标题**: *Development of a monoclonal antibody specific for HNRNPLL and its application in colorectal cancer diagnosis*
**作者**: Zhang Y, et al.
**摘要**: 报道一种针对HNRNPLL的单克隆抗体的开发，验证其在结直肠癌组织中的高表达，证明其作为潜在生物标志物的价值。
3. **标题**: *HNRNPLL-mediated splicing regulation in hepatocellular carcinoma progression*
**作者**: Li H, et al.
**摘要**: 通过免疫组化(使用HNRNPLL抗体)和RNA测序，揭示HNRNPLL在肝癌中异常剪接促癌基因的作用，关联患者预后。
4. **标题**: *Proteomic analysis of HNRNPLL interactions using RNAi and antibody-based pull-down assays*
**作者**: Kimura T, et al.
**摘要**: 结合抗体下拉实验与质谱技术，系统性分析HNRNPLL的蛋白互作网络，阐明其在转录后调控中的多效性功能。
**注意**：以上文献为示例，实际研究需以具体领域关键词(如"HNRNPLL antibody"、"hnRNP L/L-like")在PubMed/Google Scholar检索。部分研究可能涉及拼写变体(如hnRNP L或HNRNP L-like)，建议扩大检索范围。
The heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) protein, a member of the hnRNP family, plays critical roles in RNA processing, including splicing, transport, and stability. HNRNPLL is particularly notable for its involvement in regulating alternative splicing of pre-mRNA, influencing gene expression diversity in immune cells. It is essential for the development and function of adaptive immunity, particularly in B and T lymphocytes. Studies highlight its role in V(D)J recombination during antibody and T-cell receptor diversification, where it modulates RNA splicing of genes critical for lymphocyte maturation.
HNRNPLL antibodies are vital tools for investigating these mechanisms. They enable detection and localization of HNRNPLL in cellular and tissue samples via techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Research using these antibodies has linked HNRNPLL dysregulation to diseases, including hematologic malignancies like chronic lymphocytic leukemia, where aberrant splicing events contribute to pathogenesis. Additionally, HNRNPLL's interaction with RNA-binding partners and its phosphorylation-dependent regulatory functions are areas of active exploration. Reliable HNRNPLL antibodies are thus crucial for advancing understanding of post-transcriptional gene regulation in immunity and disease, offering potential therapeutic targets for splicing-related disorders.
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