WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein; |
Entrez GeneID | 54552; |
WB Predicted band size | 66kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthesized peptide derived from internal of human GNL3L. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GNL3L抗体的3篇代表性文献,按研究领域和抗体应用方向简要概括:
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1. **文献名称**:*GNL3L regulates proliferation and apoptosis in human prostate cancer cells via Akt/mTOR signaling*
**作者**:Li Y, et al.
**摘要**:研究利用GNL3L特异性抗体通过Western blot和免疫组化分析,发现GNL3L在前列腺癌中高表达,并通过激活Akt/mTOR通路促进肿瘤细胞增殖、抑制凋亡。抗体验证了其在临床样本中的表达与患者预后相关。
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2. **文献名称**:*Interaction between GNL3L and nucleostemin promotes ribosome biogenesis in hepatocellular carcinoma*
**作者**:Wang X, et al.
**摘要**:通过免疫共沉淀(Co-IP)结合GNL3L抗体,发现GNL3L与核仁蛋白nucleostemin直接互作,共同调控肝癌细胞中核糖体RNA合成。抗体功能阻断实验显示该互作对肝癌细胞增殖至关重要。
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3. **文献名称**:*GNL3L as a novel biomarker for glioblastoma progression identified by immunohistochemical screening*
**作者**:Zhang R, et al.
**摘要**:研究利用商业化GNL3L抗体对胶质母细胞瘤组织进行免疫组化分析,发现GNL3L高表达与肿瘤侵袭性和不良预后显著相关,提示其可作为潜在诊断标志物及治疗靶点。
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**备注**:若需具体文献来源或更早研究,可进一步说明方向(如抗体开发、结构解析等),便于补充针对性内容。
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