首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal GNL3L Antibody

  • 中文名: GNL3L抗体
  • 别    名: guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein;
货号: IPDX42430
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesguanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein;
Entrez GeneID54552;
WB Predicted band size66kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthesized peptide derived from internal of human GNL3L.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于GNL3L抗体的3篇代表性文献,按研究领域和抗体应用方向简要概括:

---

1. **文献名称**:*GNL3L regulates proliferation and apoptosis in human prostate cancer cells via Akt/mTOR signaling*

**作者**:Li Y, et al.

**摘要**:研究利用GNL3L特异性抗体通过Western blot和免疫组化分析,发现GNL3L在前列腺癌中高表达,并通过激活Akt/mTOR通路促进肿瘤细胞增殖、抑制凋亡。抗体验证了其在临床样本中的表达与患者预后相关。

---

2. **文献名称**:*Interaction between GNL3L and nucleostemin promotes ribosome biogenesis in hepatocellular carcinoma*

**作者**:Wang X, et al.

**摘要**:通过免疫共沉淀(Co-IP)结合GNL3L抗体,发现GNL3L与核仁蛋白nucleostemin直接互作,共同调控肝癌细胞中核糖体RNA合成。抗体功能阻断实验显示该互作对肝癌细胞增殖至关重要。

---

3. **文献名称**:*GNL3L as a novel biomarker for glioblastoma progression identified by immunohistochemical screening*

**作者**:Zhang R, et al.

**摘要**:研究利用商业化GNL3L抗体对胶质母细胞瘤组织进行免疫组化分析,发现GNL3L高表达与肿瘤侵袭性和不良预后显著相关,提示其可作为潜在诊断标志物及治疗靶点。

---

**备注**:若需具体文献来源或更早研究,可进一步说明方向(如抗体开发、结构解析等),便于补充针对性内容。

背景信息

The GNL3L (G Protein Nucleolar 3-Like) antibody is a tool used to study the GNL3L protein, which belongs to the YlqF/YawG GTPase family. GNL3L is primarily localized in the nucleolus and plays roles in ribosome biogenesis, cell proliferation, and stress response. It shares homology with nucleostemin and is implicated in regulating stem cell pluripotency and cancer progression. GNL3L interacts with key pathways, including the p53 tumor suppressor network and Myc oncogenic signaling, influencing cell cycle control and apoptosis. Research suggests its overexpression in certain cancers (e.g., gliomas, hepatocellular carcinoma) correlates with poor prognosis, while reduced expression may link to neurodegenerative conditions. The GNL3L antibody is widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and interactions in both normal and pathological contexts. Its development has advanced studies on ribosome assembly dynamics, cancer biology, and neural development, offering potential insights into therapeutic targeting. However, specificity validation remains critical due to sequence similarities with other GTPases. Ongoing research explores its dual roles in promoting tumorigenesis and maintaining neural stem cell populations.

客户数据及评论

折叠内容

大包装询价

×