Rabbit Polyclonal RPL36 Antibody

The RPL36 antibody targets ribosomal protein L36 (RPL36), a component of the 60S subunit of eukaryotic ribosomes. RPL36 plays a critical role in protein synthesis by facilitating ribosome assembly and stabilizing rRNA structure during translation. This small, highly conserved protein (human RPL36 is 148 amino acids) contains a C-terminal RNA-binding domain, enabling interactions with 28S rRNA. Antibodies against RPL36 are widely used to study ribosome biogenesis, translational regulation, and cellular stress responses linked to ribosomal dysfunction. They are valuable tools in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess RPL36 expression levels or localization. Dysregulation of RPL36 has been implicated in cancers, neurodegenerative diseases, and ribosomopathies, driving interest in its detection. Species-specific RPL36 antibodies (e.g., human, mouse) are commercially available, typically validated using knockout controls or siRNA knockdown. Some studies highlight its post-translational modifications or potential moonlighting functions beyond translation. Researchers also utilize RPL36 antibodies to investigate crosstalk between ribosome production and signaling pathways like mTOR or p53. Proper validation remains essential due to homology with RPL36 paralogs (e.g., RPL36A/B) in certain species.