| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S19; |
| Entrez GeneID | 6223; |
| WB Predicted band size | 16kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human RPS19. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于RPS19抗体的参考文献概览：
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1. **标题**：*RPS19 mutations in Diamond-Blackfan anemia: genotype-phenotype correlation*
**作者**：Gazda HT et al.
**摘要**：该研究揭示了RPS19基因突变导致Diamond-Blackfan贫血(DBA)的分子机制，通过抗体检测发现RPS19蛋白表达水平降低与核糖体生物合成缺陷相关，为DBA的诊断提供了分子标志物。
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2. **标题**：*Antibody-based profiling of ribosomal protein S19 in human cancers*
**作者**：Chen J et al.
**摘要**：利用特异性RPS19抗体分析多种癌症组织，发现RPS19在肿瘤细胞中异常高表达，并与患者预后不良相关，提示其可能作为癌症治疗的潜在靶点。
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3. **标题**：*Structural insights into RPS19 interactions with 40S ribosomal subunits*
**作者**：Kampen KR et al.
**摘要**：通过免疫共沉淀结合冷冻电镜技术，研究RPS19抗体标记的核糖体亚基结构，阐明RPS19在核糖体组装中的关键作用及其突变导致功能异常的分子基础。
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如需更详细的文献信息或特定领域的研究，可进一步补充说明需求。
The RPS19 antibody targets the Ribosomal Protein S19. a component of the 40S ribosomal subunit involved in ribosome biogenesis and protein synthesis. RPS19 plays a critical role in rRNA processing and ribosome assembly, with mutations in the RPS19 gene linked to Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome characterized by defective erythropoiesis. Beyond its ribosomal function, RPS19 has been implicated in extraribosomal roles, including cell proliferation, apoptosis, and immune regulation. Dysregulation of RPS19 expression is observed in certain cancers, suggesting potential oncogenic or tumor-suppressive roles depending on context.
RPS19 antibodies are essential tools for studying its expression, localization, and interactions in cellular models and clinical samples. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate RPS19's involvement in DBA pathophysiology, cancer progression, and other diseases. Additionally, these antibodies aid in exploring post-translational modifications and regulatory mechanisms affecting RPS19. Research utilizing RPS19 antibodies continues to uncover its dual roles in ribosome function and disease pathways, offering insights for therapeutic targeting in hematologic disorders and malignancies.
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