| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S19-binding protein 1; RPS19-binding protein 1; S19BP; |
| Entrez GeneID | 91582; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human RPS19BP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **RPS19BP1 抗体** 的模拟参考文献示例(实际文献需通过学术数据库验证)：
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1. **标题**：*RPS19BP1 regulates ribosome biogenesis and promotes cancer progression in hepatocellular carcinoma*
**作者**：Li X, Zhang Y, Chen H
**摘要**：本研究通过免疫沉淀和 Western blot 技术，利用 RPS19BP1 特异性抗体，发现 RPS19BP1 在肝癌细胞中通过调控核糖体 RNA 加工促进肿瘤增殖，并与患者预后不良相关。
2. **标题**：*Characterization of a novel polyclonal antibody against human RPS19BP1 and its application in subcellular localization*
**作者**：Wang Q, Liu F, Zhou R
**摘要**：作者开发了一种针对人源 RPS19BP1 的多克隆抗体，验证了其特异性，并通过免疫荧光技术证实 RPS19BP1 主要定位于细胞核仁，提示其在核糖体组装中的潜在作用。
3. **标题**：*RPS19BP1 interacts with c-Myc to modulate transcriptional activity in breast cancer cells*
**作者**：Kim S, Park J, Lee M
**摘要**：通过免疫共沉淀(Co-IP)结合 RPS19BP1 抗体，发现 RPS19BP1 与 c-Myc 蛋白相互作用，增强其转录活性，从而促进乳腺癌细胞侵袭和化疗耐药。
4. **标题**：*The role of RPS19BP1 in ribosomopathies: Insights from CRISPR/Cas9-mediated knockout models*
**作者**：Garcia A, Müller S, Schneider T
**摘要**：利用 RPS19BP1 抗体检测基因敲除细胞模型，发现 RPS19BP1 缺失导致核糖体生物合成异常，可能与 Diamond-Blackfan 贫血等核糖体病相关。
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**注意**：以上为模拟示例，实际文献需通过 **PubMed、Google Scholar 或 Web of Science** 检索。建议使用关键词 `RPS19BP1 antibody` 或 `RPS19BP1 function` 进行查询。
The RPS19BP1 (Ribosomal Protein S19 Binding Protein 1) antibody is a tool used to study the role of RPS19BP1. a protein that interacts with ribosomal protein S19 (RPS19). RPS19 is a component of the 40S ribosomal subunit and is critical for ribosome assembly and function. Mutations in RPS19 are linked to Diamond-Blackfan anemia (DBA), a rare genetic disorder characterized by bone marrow failure. RPS19BP1 is hypothesized to regulate RPS19 activity, potentially influencing ribosome biogenesis or modulating extraribosomal functions, such as cellular differentiation, apoptosis, or stress responses. However, the precise molecular mechanisms and biological significance of RPS19BP1 remain under investigation.
The RPS19BP1 antibody enables researchers to detect and quantify the protein in various experimental models, aiding studies on its expression patterns, subcellular localization, and interactions. It is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Understanding RPS19BP1's role could shed light on ribosomopathies, cancer (where ribosomal dysfunction is implicated), and other diseases linked to translational regulation. Current research focuses on clarifying its involvement in RPS19-related pathways and exploring its potential as a biomarker or therapeutic target. Commercial antibodies are typically validated for specificity and cross-reactivity, though validation in specific experimental contexts remains essential.
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