| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Interferon-inducible protein AIM2; Absent in melanoma 2; AIM2; |
| Entrez GeneID | 9447; |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human AIM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AIM2抗体的3篇代表性文献，按研究方向和内容概括整理：
1. **文献名称**：AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome
**作者**：Hornung V. et al. (2010)
**摘要**：首次阐明AIM2蛋白通过其HIN结构域直接结合细胞质双链DNA，并组装炎症小体激活caspase-1.促进IL-1β成熟。研究利用AIM2抗体验证蛋白表达和定位。
2. **文献名称**：Cytosolic DNA sensing through AIM2 engages the inflammasome in macrophages
**作者**：Jakobs C. et al. (2015)
**摘要**：揭示AIM2通过识别病原体或自身DNA激活炎症反应，使用特异性抗体证明其在巨噬细胞中的功能调控，并发现其与自身免疫疾病的潜在关联。
3. **文献名称**：AIM2 inflammasome activation regulates epithelial integrity in colorectal cancer
**作者**：Man S.M. et al. (2018)
**摘要**：发现AIM2在结直肠癌中通过维持肠道屏障完整性抑制肿瘤转移，研究中利用AIM2抗体检测组织样本中的蛋白表达水平，提示其作为预后标志物的潜力。
4. **文献名称**：Autoantibodies targeting AIM2 in systemic lupus erythematosus
**作者**：Dombrowski Y. et al. (2020)
**摘要**：报道SLE患者血清中存在抗AIM2自身抗体，通过ELISA和免疫印迹验证其存在，提示这类抗体可能干扰天然免疫应答并加重疾病进程。
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以上文献覆盖AIM2的结构功能、疾病机制及抗体应用场景，适合作为研究AIM2抗体在基础科研或临床检测中的参考依据。
The AIM2 (Absent in Melanoma 2) antibody is a tool used to study the AIM2 protein, a key component of the innate immune system. AIM2 belongs to the PYHIN protein family and functions as a cytosolic DNA sensor. It recognizes double-stranded DNA (dsDNA) from pathogens (e.g., viruses, bacteria) or self-DNA released during cellular stress or damage. Upon binding to dsDNA, AIM2 forms an inflammasome complex by recruiting ASC and caspase-1. leading to the activation of inflammatory cytokines (e.g., IL-1β, IL-18) and induction of pyroptosis, a form of programmed cell death. This mechanism is critical for host defense and has implications in autoimmune diseases, infections, and cancer.
AIM2 antibodies are widely used in research to detect AIM2 expression, study its interaction partners, and explore its role in diseases. For example, dysregulated AIM2 signaling is linked to autoimmune disorders (e.g., psoriasis, lupus) and cancer progression, where AIM2 can act as both a tumor suppressor and promoter depending on context. Antibodies targeting AIM2 help elucidate its dual roles in inflammation and cancer, aiding in the development of therapeutic strategies. Structurally, AIM2 contains an N-terminal pyrin domain (PYD) for protein interactions and a C-terminal HIN domain for DNA binding. Its antibody applications include Western blotting, immunofluorescence, and immunohistochemistry, supporting both basic research and clinical diagnostics.
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