Rabbit Polyclonal ADD3 Antibody

The ADD3 antibody targets adducin gamma (ADD3), a member of the adducin family of cytoskeletal proteins involved in regulating membrane integrity, cell-cell adhesion, and signal transduction. Adducins form heterodimers or heterotetramers, binding to spectrin-actin complexes to stabilize the cytoskeleton and influence ion transport. ADD3. primarily expressed in the brain, kidney, and liver, exists as multiple isoforms due to alternative splicing. Its phosphorylation modulates interactions with spectrin and actin, affecting cell morphology and motility. Dysregulation of ADD3 is linked to diseases such as hypertension, biliary atresia, and cancers. For instance, reduced ADD3 expression correlates with tumor progression and metastasis in hepatocellular carcinoma. The ADD3 antibody is widely used in research to study protein localization, expression levels, and functional roles via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps elucidate mechanisms underlying cytoskeletal dynamics, cellular stress responses, and disease pathology. Species reactivity typically includes human, mouse, and rat, with validation in specific experimental models. Commercial antibodies are often validated for specificity using knockout controls or peptide blocking assays. Research on ADD3 continues to explore its potential as a therapeutic target or diagnostic marker in metabolic and neoplastic disorders.