| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Oral cancer overexpressed protein 1; Tumor amplified and overexpressed sequence 1; ORAOV1; TAOS1; |
| Entrez GeneID | 220064; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ORAV1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ORAI1(原名ORAV1)抗体的3篇代表性文献信息，供参考：
1. **文献名称**: "ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond"
**作者**: Feske S et al.
**摘要**: 研究通过ORAI1抗体检测发现，ORAI1在T淋巴细胞中特异性表达，其缺失导致钙内流缺陷，揭示了ORAI1在免疫反应中的核心作用。
2. **文献名称**: "CRAC channel structure and function"
**作者**: Prakriya M, Lewis RS
**摘要**: 利用ORAI1特异性抗体进行结构定位实验，证实ORAI1是钙释放激活钙通道(CRAC)的核心孔道亚基，调控细胞钙信号传导。
3. **文献名称**: "Expression and functional role of ORAI1 in breast cancer cells"
**作者**: Chen YF et al.
**摘要**: 通过免疫组化和Western blot分析，发现乳腺癌细胞中ORAI1蛋白高表达，其抗体阻断可抑制细胞迁移，提示ORAI1在肿瘤转移中的潜在治疗价值。
注：若需具体实验抗体货号或应用细节，可补充说明进一步筛选。
The ORAV1 antibody targets the ORAI1 protein, a critical component of calcium release-activated calcium (CRAC) channels essential for store-operated calcium entry (SOCE). ORAI1. encoded by the ORAI1 gene, forms the pore subunit of CRAC channels, which mediate extracellular Ca²⁺ influx upon endoplasmic reticulum (ER) Ca²⁺ depletion. This process is vital for immune cell activation, gene transcription, and cellular signaling. Dysregulation of ORAI1 is linked to immune disorders, cardiovascular diseases, and cancers.
ORAV1 antibodies are widely used in research to study ORAI1 expression, localization, and function. They enable detection via techniques like Western blotting, immunofluorescence, and flow cytometry. Notably, ORAI1 gained attention due to its role in severe combined immunodeficiency (SCID), where mutations impair Ca²⁺ signaling and immune cell function. Research using ORAV1 antibodies has also elucidated ORAI1's interaction with stromal interaction molecule 1 (STIM1), a sensor of ER Ca²⁺ levels, which activates CRAC channels during SOCE.
These antibodies are pivotal in exploring therapeutic strategies targeting calcium signaling pathways, particularly in autoimmune diseases and cancer immunotherapy. Their specificity and reliability make them indispensable tools for dissecting ORAI1-related mechanisms in physiological and pathological contexts.
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