| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 596; ZNF596; |
| Entrez GeneID | 169270; |
| WB Predicted band size | 58kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ZNF596. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF596抗体的3篇示例文献(内容为虚构示例，仅作格式参考)：
1. **文献名称**：*ZNF596 Antibody Development for Epigenetic Research*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性兔源ZNF596多克隆抗体，验证了其在染色质免疫沉淀(ChIP)中的有效性，证实ZNF596通过与特定DNA序列结合调控表观遗传修饰。
2. **文献名称**：*Role of ZNF596 in Glioblastoma Progression: Insights from Antibody-Based Assays*
**作者**：Chen L, et al.
**摘要**：利用商业化ZNF596单克隆抗体进行免疫组化分析，发现ZNF596在胶质母细胞瘤中异常高表达，并与其侵袭性相关，提示其作为潜在治疗靶点。
3. **文献名称**：*Characterization of ZNF596 Antibody for Western Blot and Immunofluorescence*
**作者**：Wang Y, et al.
**摘要**：系统评估了ZNF596抗体的交叉反应性和灵敏度，证实其适用于Western blot及细胞免疫荧光，为研究ZNF596的亚细胞定位提供可靠工具。
(注：以上文献为模拟内容，实际引用需查询PubMed、Google Scholar等平台获取真实数据。)
The zinc finger protein 596 (ZNF596) is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which plays roles in transcriptional regulation and chromatin remodeling. ZNF596 is characterized by multiple C2H2-type zinc finger motifs, enabling sequence-specific DNA or RNA binding, and a KRAB domain that often mediates interactions with co-repressors to modulate gene expression. Though less studied than other ZNF proteins, emerging research suggests ZNF596 may participate in cellular processes such as proliferation, differentiation, and apoptosis. It has been implicated in cancer biology, with studies reporting both tumor-suppressive and oncogenic roles depending on context. For example, ZNF596 was shown to suppress breast cancer metastasis by regulating epithelial-mesenchymal transition (EMT), while other evidence links its overexpression to poor prognosis in colorectal cancer.
ZNF596 antibodies are tools developed to detect and study this protein's expression, localization, and function. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Some antibodies target specific regions, such as the N-terminal KRAB domain or C-terminal zinc finger clusters. Commercial antibodies are available from suppliers like Sigma-Aldrich and Santa Cruz Biotechnology, often validated in human or mouse models. Challenges include ensuring specificity due to structural similarities among ZNF family members. Recent studies using ZNF596 antibodies have explored its interaction with viral proteins and involvement in DNA damage response pathways. However, further validation via knockout/knockdown controls is recommended to confirm antibody reliability in experimental settings.
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