Rabbit Polyclonal ES8L1 Antibody

ES8L1 is a monoclonal antibody primarily recognized for its reactivity with a specific epitope on intermediate filament proteins, particularly cytokeratins. Cytokeratins are structural proteins expressed in epithelial cells and are widely used as biomarkers in pathological studies to identify epithelial-derived tumors or assess cellular differentiation. The ES8L1 clone was developed to target cytokeratin 18 (CK18), a type I intermediate filament protein abundantly expressed in simple and glandular epithelia. This antibody has been extensively utilized in immunohistochemistry (IHC) and immunofluorescence (IF) applications to study tissue architecture, tumor classification, and metastasis in cancers such as carcinomas. Its specificity for CK18 makes it valuable in distinguishing epithelial malignancies from other tumor types, aiding in diagnostic workflows. ES8L1's robust performance in formalin-fixed, paraffin-embedded (FFPE) tissues further enhances its utility in clinical and research settings. While the exact immunogen and development details remain proprietary, ES8L1 is commercially available through multiple biotechnology vendors, underscoring its established role in epithelial biology research. Studies have also explored its potential in monitoring apoptosis, as CK18 cleavage is a hallmark of programmed cell death. Overall, ES8L1 serves as a critical tool for investigating epithelial cell behavior, cancer diagnostics, and cellular mechanisms underlying disease progression.