| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neurogenic differentiation factor 2; NeuroD2; NeuroD-related factor; NDRF; NEUROD2 |
| Entrez GeneID | 4761; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human NDF2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NDF2抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：
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1. **文献名称**：*NDF2 Antibody Characterization in Neuronal Differentiation Studies*
**作者**：Smith A, et al.
**摘要**：本研究验证了NDF2抗体的特异性，通过Western blot和免疫荧光技术证明其在哺乳动物神经元分化模型中检测NDF2蛋白的表达变化，并揭示其与突触形成相关的功能。
2. **文献名称**：*Role of NDF2 in Cancer Metastasis: Insights from Antibody-Based Inhibition*
**作者**：Chen L, et al.
**摘要**：利用NDF2单克隆抗体阻断肿瘤细胞中的NDF2活性，发现其显著抑制癌细胞迁移和侵袭，提示NDF2可能作为癌症治疗的潜在靶点。
3. **文献名称**：*Development of a High-Affinity NDF2 Polyclonal Antibody for Epigenetic Research*
**作者**：Yamamoto K, et al.
**摘要**：报道了一种新型NDF2多克隆抗体的开发，验证其在染色质免疫沉淀(ChIP)中的应用，揭示NDF2与特定基因启动子区域的结合调控表观遗传修饰。
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**说明**：以上文献为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索。建议结合具体研究背景(如疾病模型、实验方法)优化关键词(如“NDF2 antibody + Western blot + cancer”)。
The NDF2 antibody is designed to target Neuregulin-2 (NRG2), a member of the neuregulin family of growth factors that play critical roles in cell signaling, particularly within the ErbB receptor tyrosine kinase network. NRG2 binds to ErbB3 and ErbB4 receptors, activating downstream pathways involved in cell proliferation, differentiation, and survival. This protein is especially significant in neural development, cardiac function, and cancer biology, where dysregulated neuregulin signaling has been implicated in tumor progression and metastasis.
The NDF2 antibody is commonly utilized in research to study NRG2 expression and function across various tissues and disease models. It enables detection of NRG2 isoforms via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of its role in physiological processes and pathologies such as breast cancer, schizophrenia, and cardiovascular diseases. Commercial NDF2 antibodies are typically validated for specificity and sensitivity, often derived from immunized hosts like rabbits or mice.
Recent studies highlight its application in identifying NRG2 as a potential therapeutic target or biomarker, particularly in cancers with ErbB receptor overexpression. However, variability in antibody performance across experimental conditions underscores the need for rigorous validation. Overall, the NDF2 antibody serves as a vital tool for unraveling the complex signaling mechanisms of neuregulins and their implications in health and disease.
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