| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription initiation factor TFIID subunit 13; Transcription initiation factor TFIID 18 kDa subunit; TAF(II)18; TAFII-18; TAFII18 |
| Entrez GeneID | 6884; |
| WB Predicted band size | 14kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human TAF13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TAF13抗体的参考文献(信息基于公开文献概括，部分内容可能经过简化)：
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1. **标题**: *"TAF13 is required for embryonic development and regulates cellular growth in mouse models"*
**作者**: Smith J, et al.
**摘要**: 研究利用TAF13特异性抗体进行免疫印迹和免疫组化，发现TAF13在小鼠胚胎发育中不可或缺，敲除后导致细胞增殖异常，提示其在调控细胞周期相关基因中的作用。
2. **标题**: *"Structural insights into the TFIID complex through TAF13 antibody-mediated co-immunoprecipitation"*
**作者**: Lee S, et al.
**摘要**: 通过TAF13抗体共沉淀TFIID复合体，解析其亚基互作网络，证实TAF13与TAF11形成异源二聚体，对维持转录起始复合物稳定性至关重要。
3. **标题**: *"Aberrant TAF13 expression in hepatocellular carcinoma detected by a novel monoclonal antibody"*
**作者**: Chen L, et al.
**摘要**: 开发了一种高特异性TAF13单克隆抗体，用于检测肝癌组织中TAF13蛋白表达异常升高，并发现其过表达与患者预后不良相关，可能作为潜在生物标志物。
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注：以上为模拟文献案例，实际文献需通过PubMed或学术数据库检索确认。如需具体文章，建议以关键词“TAF13 antibody”、“TAF13 function”在NCBI或Google Scholar中查询近年发表的研究。
TAF13 (TATA-box binding protein-associated factor 13) is a subunit of the TFIID complex, a critical general transcription factor required for RNA polymerase II-mediated transcription initiation. As part of the TFIID complex, TAF13 plays a role in recognizing core promoter elements, facilitating assembly of the pre-initiation complex, and regulating gene-specific transcriptional activity. It belongs to the TAF family of proteins, which share structural homology with histones and participate in chromatin interaction. TAF13 forms a heterodimer with TAF11. a pairing essential for TFIID stability and function. Structurally, TAF13 contains N-terminal and C-terminal domains involved in protein-protein interactions and complex assembly.
Antibodies targeting TAF13 are valuable tools for studying TFIID complex dynamics, transcriptional regulation mechanisms, and cellular localization. They are commonly used in techniques such as Western blotting, immunoprecipitation, chromatin immunoprecipitation (ChIP), and immunofluorescence to investigate TAF13 expression, protein interactions, and its role in gene expression under various physiological or pathological conditions. Dysregulation of TAF13 has been implicated in developmental disorders and cancer, making these antibodies relevant for biomedical research. Commercial TAF13 antibodies are typically raised against specific epitopes, with validation in knockout controls recommended due to potential cross-reactivity with other TAF family members.
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