Rabbit Polyclonal TAF5 Antibody

The TAF5 antibody targets the TATA-box binding protein-associated factor 5 (TAF5), a critical subunit of the TFIID complex, which is essential for RNA polymerase II-mediated transcription initiation. TAF5 plays a structural and functional role in assembling the TFIID multiprotein complex, facilitating promoter recognition and recruitment of coactivators. It also interacts with histone acetyltransferases and other chromatin-modifying enzymes, linking transcription initiation to epigenetic regulation. Dysregulation of TAF5 has been implicated in cellular processes such as differentiation, cell cycle control, and apoptosis, with aberrant expression observed in cancers and developmental disorders. Antibodies against TAF5 are widely used in research to study TFIID complex dynamics, transcriptional mechanisms, and disease pathways. They enable techniques like Western blotting, immunoprecipitation, and chromatin immunoprecipitation (ChIP) to investigate TAF5's localization, interactions, and regulatory roles. Commercial TAF5 antibodies are typically validated for specificity in human, mouse, or rat models, aiding in both basic and translational studies. Recent studies also explore TAF5's involvement in maintaining pluripotency in stem cells, highlighting its broader significance in cellular identity and disease.