Rabbit Polyclonal DRP1(Ab-637) Antibody

The DRP1 (Ab-637) antibody is a widely used tool for studying dynamin-related protein 1 (DRP1), a key regulator of mitochondrial fission. DRP1. encoded by the *DNM1L* gene, is a cytosolic GTPase that translocates to mitochondria to mediate membrane scission, maintaining mitochondrial dynamics and quality control. Dysregulation of DRP1 activity is linked to neurodegenerative diseases, metabolic disorders, and cancer, making it a critical target for research. The Ab-637 antibody specifically recognizes total DRP1 protein across species, including human, mouse, and rat, enabling applications like Western blotting, immunofluorescence, and immunoprecipitation. It is often employed to investigate DRP1’s post-translational modifications (e.g., phosphorylation at Ser616 or Ser637) or interactions with mitochondrial adaptors like Fis1 and MFF. Researchers use this antibody to explore DRP1’s role in apoptosis, mitophagy, and cellular stress responses. Its reliability in detecting endogenous DRP1 levels under diverse experimental conditions has made it a staple in studies of mitochondrial dysfunction and therapeutic targeting. Validation typically includes knockout controls to confirm specificity. By enabling precise detection of DRP1 expression and localization, Ab-637 supports mechanistic insights into mitochondrial dynamics and their implications in disease pathogenesis.