| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EK4; EPH receptor A3; EPH-like kinase 4; eph-like tyrosine kinase 1; EPHA3 |
| Entrez GeneID | 2042; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human EPHA3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 EPHA3 (Ab-602) 抗体的示例参考文献(内容为示例，实际文献需通过学术数据库验证)：
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1. **文献名称**: *"EPHA3 expression in non-small cell lung cancer and its role in tumor progression"*
**作者**: Chen Y, et al.
**摘要**: 研究使用 EPHA3 (Ab-602) 抗体通过免疫组化分析非小细胞肺癌组织中 EPHA3 的表达水平，发现其高表达与肿瘤转移和患者生存率降低显著相关，提示 EPHA3 可能作为肺癌预后标志物。
2. **文献名称**: *"Targeting EPHA3 in glioblastoma: Antibody-based therapeutic strategies"*
**作者**: Wang L, et al.
**摘要**: 利用 EPHA3 (Ab-602) 抗体在胶质母细胞瘤模型中验证 EPHA3 的过表达，并通过体外实验证明该抗体可抑制肿瘤细胞增殖并诱导凋亡，为靶向治疗提供依据。
3. **文献名称**: *"EPHA3 regulates endothelial cell migration via Ab-602 antibody-mediated signaling blockade"*
**作者**: Smith JR, et al.
**摘要**: 通过 EPHA3 (Ab-602) 抗体阻断 EphA3 受体与配体相互作用，发现其显著抑制内皮细胞迁移和血管生成，揭示了 EPHA3 在血管重塑中的关键作用。
4. **文献名称**: *"Validation of EPHA3 antibody (Ab-602) for flow cytometry and Western blot applications"*
**作者**: Gupta S, et al.
**摘要**: 系统性验证 EPHA3 (Ab-602) 抗体在流式细胞术和蛋白质印迹中的特异性，确认其适用于多种实验条件，为后续研究提供技术参考。
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**提示**：实际文献需通过 PubMed、Web of Science 或 Google Scholar 等平台检索关键词“EPHA3 antibody Ab-602”或结合研究领域(如癌症、信号通路)进一步筛选。
The EPHA3 (Ab-602) antibody is a monoclonal antibody specifically designed to target the Ephrin type-A receptor 3 (EPHA3), a member of the Eph receptor tyrosine kinase family. EPHA3 plays critical roles in cell-cell communication, tissue patterning, and developmental processes by binding to membrane-anchored ephrin ligands. Dysregulation of EPHA3 has been implicated in various cancers, including leukemia, glioblastoma, and lung adenocarcinoma, where it may influence tumor progression, metastasis, and drug resistance.
The Ab-602 clone recognizes an epitope within the extracellular domain of human EPHA3. making it suitable for detecting endogenous EPHA3 protein in applications such as Western blotting, immunohistochemistry (IHC), and flow cytometry. It is commonly used in research to explore EPHA3's functional roles in oncogenic signaling, cell adhesion, and migration mechanisms. Validated in multiple model systems, this antibody has contributed to studies identifying EPHA3 as a potential therapeutic target or biomarker in malignancies.
Originally derived from murine hybridoma cells, the Ab-602 antibody is often available in unconjugated or conjugated forms (e.g., HRP, FITC) to accommodate diverse experimental needs. Researchers prioritize its use due to its specificity and reproducibility in both normal and pathological tissues. Ongoing investigations continue to unravel EPHA3's dual role as a tumor suppressor or promoter, depending on cellular context, underscoring the antibody's relevance in translational cancer research.
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