| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IL10R |
| Entrez GeneID | 3587; |
| WB Predicted band size | 63kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.368~372 (T-D-S-G-I) derived from Human IL10RA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于IL10RA (Ab-370)抗体的3篇假设性参考文献，供参考：
---
1. **文献名称**：*IL-10 Receptor Signaling in Macrophage Polarization and Inflammation*
**作者**：Smith A, et al.
**摘要**：本研究利用IL10RA (Ab-370)抗体通过Western blot和流式细胞术，揭示了IL-10通过结合IL10RA调控巨噬细胞向抗炎表型分化的机制，并发现该通路缺陷可能加重实验性结肠炎。
2. **文献名称**：*Mutations in IL10RA Linked to Early-Onset Inflammatory Bowel Disease*
**作者**：Johnson R, et al.
**摘要**：通过免疫组化(使用Ab-370抗体)和基因测序，研究团队发现IL10RA基因突变导致受体表达异常，破坏IL-10介导的抗炎信号，与儿童炎症性肠病(IBD)发病密切相关。
3. **文献名称**：*IL-10/STAT3 Pathway in Tumor Microenvironment Immunosuppression*
**作者**：Lee X, et al.
**摘要**：研究使用Ab-370抗体检测肿瘤组织中IL10RA的表达水平，证实IL-10通过激活STAT3通路抑制树突状细胞功能，为靶向IL10RA的癌症免疫治疗提供依据。
---
*注：以上文献为示例，实际引用时需根据真实发表的论文信息进行核实。Ab-370抗体编号可能对应特定厂商(如CST公司产品)，建议查阅抗体说明书或相关数据库(如CiteAb)获取准确文献。*
The IL10RA (Ab-370) antibody is a monoclonal or polyclonal reagent designed to specifically target the interleukin-10 receptor alpha subunit (IL10RA), a critical component of the IL-10 signaling pathway. IL10RA is a transmembrane protein that binds IL-10. an anti-inflammatory cytokine essential for modulating immune responses, suppressing excessive inflammation, and maintaining tissue homeostasis. This receptor forms a heterodimer with IL10RB to activate downstream signaling cascades, primarily involving the JAK1/STAT3 pathway, which regulates immune cell function and cytokine production. Dysregulation of IL10RA is linked to inflammatory bowel disease (IBD), autoimmune disorders, and certain cancers.
The IL10RA (Ab-370) antibody is commonly used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to detect IL10RA expression, localization, or post-translational modifications in cells and tissues. Its specificity is often validated through knockout controls or siRNA-mediated silencing. Researchers employ this tool to investigate IL-10's role in immune tolerance, tumor microenvironment modulation, and inflammatory disease mechanisms. As IL10RA-targeted therapies gain interest for treating chronic inflammation or cancer, this antibody also serves as a valuable reagent for preclinical studies evaluating receptor expression patterns or therapeutic efficacy.
×
