Rabbit Polyclonal Id2 Antibody

The Id2 (Inhibitor of DNA binding 2) antibody is a tool used to detect and study the Id2 protein, a member of the helix-loop-helix (HLH) transcriptional regulator family. Id proteins, including Id1-4. lack the basic DNA-binding domain found in canonical HLH transcription factors, enabling them to act as dominant-negative regulators by sequestering E-proteins or other HLH partners. Id2 plays critical roles in cellular processes such as differentiation, proliferation, and apoptosis. It is particularly notable in development, where it regulates cell fate decisions in neural, immune, and stem cell systems. In cancer research, Id2 exhibits dual roles: it can suppress tumorigenesis by promoting cell cycle exit or drive malignancy by enhancing proliferation, depending on cellular context. Dysregulation of Id2 is linked to cancers like neuroblastoma, breast cancer, and glioblastoma. The Id2 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and flow cytometry to assess protein expression levels in tissues or cultured cells. Its applications span developmental biology, oncology, and stem cell studies, aiding in understanding mechanisms of tumor progression, differentiation pathways, and tissue homeostasis. Commercial Id2 antibodies are typically validated for specificity against conserved regions of the protein across species.