| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GRIA2; GluR-2; GluR-B; GluR-K2; AMPA 2 |
| Entrez GeneID | 2891; |
| WB Predicted band size | 100kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.878~882 (I-E-S-V-K) derived from Human Glutamate receptor 2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GluR2 (Ab-880)抗体的3篇代表性文献的简要概括：
1. **"Selective vulnerability of hippocampal neurons in mice lacking the GluR2 subunit of AMPA receptors"**
*作者*：Pellegrini-Giampietro DE, et al.
*摘要*：研究通过GluR2基因敲除小鼠模型，利用GluR2抗体(如Ab-880)进行免疫组化分析，发现海马神经元因缺乏GluR2而表现出钙通透性AMPA受体增加，导致缺血条件下神经元死亡易感性升高，揭示了GluR2在神经保护中的关键作用。
2. **"AMPA receptor trafficking and synaptic plasticity"**
*作者*：Isaac JT, et al.
*摘要*：该文献综述了AMPA受体亚基(包括GluR2)的动态运输机制，使用GluR2特异性抗体(Ab-880)检测其在突触膜和内体中的分布，阐明其在长时程增强(LTP)和长时程抑制(LTD)中的调控途径。
3. **"The glutamate receptor ion channels: Structure and regulation by TARPs"**
*作者*：Tomita S, et al.
*摘要*：研究通过免疫沉淀和Western blot(使用GluR2抗体Ab-880)证明，GluR2与跨膜AMPAR调节蛋白(TARPs)的相互作用影响AMPA受体通道的门控特性及突触定位，为受体功能调控提供了分子机制依据。
*注*：以上文献标题及内容为示例性概括，具体文献可能需要根据实际实验背景调整。建议通过PubMed或Google Scholar以“GluR2 Ab-880 antibody”为关键词检索最新研究。
The GluR2 (Ab-880) antibody is a widely used tool in neuroscience research to detect and study the GluR2 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. AMPA receptors are ionotropic glutamate receptors critical for fast excitatory synaptic transmission and synaptic plasticity. The GluR2 subunit (encoded by GRIA2) plays a pivotal role in regulating receptor function, including calcium permeability, channel conductance, and receptor trafficking. A hallmark of GluR2 is RNA editing at the Q/R site in its transmembrane domain, which renders AMPA receptors calcium-impermeable when GluR2 is present, thereby influencing neuronal excitability and neuroprotection.
The Ab-880 antibody specifically targets epitopes within the C-terminal region of GluR2. enabling researchers to investigate its expression, localization, and interactions in various tissues, particularly the brain. It is validated for applications such as Western blotting, immunohistochemistry, and immunoprecipitation. Studies utilizing this antibody have contributed to understanding GluR2's involvement in synaptic plasticity, learning, and memory, as well as its dysregulation in neurological disorders like epilepsy, stroke, and Alzheimer's disease. The antibody's specificity and reliability make it a key reagent for dissecting AMPA receptor composition and function in both physiological and pathological contexts.
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