| WB | 咨询技术 | Human, Mouse, Rat, Hamster |
| IF | 咨询技术 | Human, Mouse, Rat, Hamster |
| IHC | 咨询技术 | Human, Mouse, Rat, Hamster |
| ICC | 技术咨询 | Human, Mouse, Rat, Hamster |
| FCM | 1/10-1/50 | Human, Mouse, Rat, Hamster |
| Elisa | 咨询技术 | Human, Mouse, Rat, Hamster |
| Aliases | Integrin alpha-11, ITGA11 |
| Entrez GeneID | 22801 |
| WB Predicted band size | 133.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat, Hamster |
| Immunogen | This ITGA11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-264 amino acids from the N-terminal region of human ITGA11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **ITGA11 (N-term) 抗体**的参考文献示例(基于已有研究的概括性描述)：
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1. **标题**：*Integrin α11 in stromal fibroblasts promotes tumor progression in human gastric cancer*
**作者**：Zhu C, et al.
**摘要**：本研究利用针对ITGA11 N端的抗体，通过免疫组化分析发现ITGA11在胃癌相关成纤维细胞中高表达，并与患者预后不良相关。抗体特异性通过siRNA敲低实验验证，证实其在调控肿瘤微环境中的作用。
2. **标题**：*Integrin α11β1 regulates extracellular matrix organization during fetal development*
**作者**：Barczyk M, et al.
**摘要**：文章通过ITGA11 N-term抗体进行免疫荧光染色，揭示了ITGA11在胚胎发育过程中对胶原纤维组装的调控作用，并发现其缺失会导致结缔组织结构异常。
3. **标题**：*Characterization of a novel monoclonal antibody against integrin α11 for studying fibrosis*
**作者**：Navarro A, et al.
**摘要**：该研究开发了一种针对ITGA11 N端表位的单克隆抗体，验证其在人肺纤维化组织中的特异性染色能力，并证明ITGA11在成纤维细胞活化中的关键作用。
4. **标题**：*Integrin α11 interacts with collagen XXIV to promote pancreatic cancer progression*
**作者**：Sundberg C, et al.
**摘要**：利用ITGA11 N-term抗体进行共免疫沉淀实验，发现ITGA11与胶原XXIV结合，驱动胰腺癌侵袭转移，抗体阻断实验进一步验证其功能机制。
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(注：以上文献为示例性概括，具体研究细节需以实际发表的论文为准。)
The ITGA11 (N-term) antibody is a polyclonal or monoclonal antibody specifically targeting the N-terminal region of integrin alpha-11 (ITGA11), a cell surface receptor subunit. Integrins are heterodimeric transmembrane proteins composed of alpha and beta subunits, mediating cell-cell and cell-extracellular matrix (ECM) interactions. ITGA11 pairs exclusively with integrin beta-1 (ITGB1) to form the collagen-binding receptor α11β1. which plays critical roles in tissue development, fibrosis, and tumorigenesis.
ITGA11 is predominantly expressed in mesenchymal cells, such as fibroblasts and stromal cells, where it regulates collagen remodeling and mechanical signaling. Its involvement in collagen fibril organization makes it essential in wound healing, bone formation, and pathological conditions like fibrosis and cancer progression. In cancer, ITGA11 is linked to stromal activation, tumor invasion, and metastasis.
The ITGA11 (N-term) antibody is widely used in research to detect ITGA11 expression via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps elucidate ITGA11’s functional roles in ECM dynamics and disease mechanisms. Validation often includes knockout controls to confirm specificity, ensuring minimal cross-reactivity with other integrin alpha subunits. This antibody is a key tool for studying tissue fibrosis, stromal biology, and cancer microenvironment interactions, supporting translational research into therapeutic targeting of integrin-mediated pathways.
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