Rabbit Polyclonal HHIPL2 Antibody

The HHIPL2 (Hedgehog-interacting protein-like 2) antibody is a research tool designed to detect and study the HHIPL2 protein, a less-characterized member of the Hedgehog (Hh) signaling pathway. HHIPL2 shares structural homology with HHIP, a known regulator of Hh signaling that binds to Hh ligands (e.g., Sonic Hedgehog) to modulate developmental processes, tissue homeostasis, and disease pathways. While HHIP is well-studied in embryogenesis, cancer, and fibrosis, HHIPL2's exact biological roles remain unclear, though it is hypothesized to participate in similar regulatory mechanisms or ligand-receptor interactions. Emerging studies suggest HHIPL2 may influence cardiovascular development and pathologies, with associations identified in aortic aneurysms and vascular remodeling. Its expression has also been noted in certain cancers, though functional data are limited. The HHIPL2 antibody enables researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validating antibody specificity is critical due to potential cross-reactivity with homologous proteins like HHIP. Current research focuses on clarifying HHIPL2's role in Hh signaling crosstalk, disease mechanisms, and its potential as a therapeutic target or biomarker. Further studies using this antibody could elucidate its contributions to developmental and pathological processes.