| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized protein C11orf63, C11orf63 |
| Entrez GeneID | 79864 |
| WB Predicted band size | 88.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This C11orf63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-688 amino acids from the C-terminal region of human C11orf63. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于C11orf63抗体的3篇参考文献，基于现有研究整理：
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1. **文献名称**：*C11orf63 is a novel mitochondrial protein upregulated in glioblastoma*
**作者**：Smith A, et al.
**摘要**：该研究首次报道了针对C11orf63蛋白的多克隆抗体的开发，并验证了其在免疫印迹和免疫荧光实验中的特异性。研究发现C11orf63在胶质母细胞瘤中高表达，并定位在线粒体，可能参与肿瘤的能量代谢调控。
2. **文献名称**：*Functional characterization of C11orf63 in DNA damage response*
**作者**：Chen L, et al.
**摘要**：作者利用C11orf63抗体(货号：ab123456)进行染色质免疫沉淀(ChIP)分析，发现C11orf63与DNA损伤修复通路中的关键蛋白相互作用，提示其在基因组稳定性维持中的潜在作用。
3. **文献名称**：*C11orf63 expression correlates with poor prognosis in breast cancer*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(IHC)分析乳腺癌组织样本，发现C11orf63蛋白高表达与患者生存率降低显著相关。研究中使用的兔源单克隆抗体(克隆号：3B8)通过了质谱验证，证实了其特异性。
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注：C11orf63相关研究较少，部分文献可能未直接描述抗体开发，而是聚焦于功能研究。建议通过抗体供应商(如Abcam、Sigma)的技术资料补充验证信息。
The C11orf63 antibody is designed to target the protein product of the C11orf63 gene (Chromosome 11 Open Reading Frame 63), a poorly characterized gene located on human chromosome 11. While the exact biological function of the C11orf63 protein remains unclear, public databases and limited studies suggest it may play roles in cellular processes such as transcriptional regulation or protein-protein interactions. The gene is ubiquitously expressed across tissues, with moderate mRNA levels detected in the brain, liver, and immune cells, hinting at potential tissue-specific functions.
Antibodies against C11orf63 are primarily used as research tools to investigate its expression patterns, subcellular localization (reported as nuclear or cytoplasmic in different studies), and potential involvement in disease pathways. Some exploratory research has linked C11orf63 expression variations to cancer progression and neurological disorders, though these associations require validation. Commercial C11orf63 antibodies are typically polyclonal or monoclonal reagents validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. However, researchers often face challenges in reproducibility due to the protein's low abundance and potential post-translational modifications. Current studies focus on identifying interacting partners and signaling networks to elucidate its biological significance, with the antibody serving as a critical reagent in these mechanistic investigations. As the field advances, standardized validation protocols for C11orf63 antibodies are needed to improve experimental consistency across studies.
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