| WB | 1/2000 | Human, Mouse, Rat, African Green Mouseonkey |
| IF | 咨询技术 | Human, Mouse, Rat, African Green Mouseonkey |
| IHC | 咨询技术 | Human, Mouse, Rat, African Green Mouseonkey |
| ICC | 技术咨询 | Human, Mouse, Rat, African Green Mouseonkey |
| FCM | 咨询技术 | Human, Mouse, Rat, African Green Mouseonkey |
| Elisa | 咨询技术 | Human, Mouse, Rat, African Green Mouseonkey |
| Aliases | Ras-related protein Rab-21, RAB21, KIAA0118 |
| Entrez GeneID | 23011 |
| WB Predicted band size | 24.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat, African Green Mouseonkey |
| Immunogen | This RAB21 antibody is generated from a mouse immunized with a recombinant protein between 1-225 amino acids from the human RAB21. |
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以下是3篇关于RAB21抗体的参考文献示例(文献信息为虚构示例，仅用于展示格式)：
1. **文献名称**: "RAB21 regulates integrin trafficking and cell migration"
**作者**: Smith A, et al.
**摘要**: 研究使用RAB21抗体进行免疫荧光染色，发现RAB21通过调控β1整合素的内吞循环影响细胞迁移，揭示了其在癌症转移中的潜在作用。
2. **文献名称**: "RAB21 modulates autophagy through interaction with ATG9A"
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫共沉淀实验(使用RAB21抗体)，证明RAB21与自噬相关蛋白ATG9A结合，调控自噬小体形成，影响细胞应激反应。
3. **文献名称**: "RAB21 antibody-based profiling in neurodegenerative diseases"
**作者**: García-Ruiz C, et al.
**摘要**: 利用特异性RAB21抗体分析阿尔茨海默病患者脑组织，发现RAB21在异常蛋白聚集区域的表达升高，提示其与神经退行性病变相关。
4. **文献名称**: "Role of RAB21 in bacterial pathogen internalization"
**作者**: Tanaka K, et al.
**摘要**: 通过siRNA敲低和RAB21抗体标记实验，证明RAB21通过调控细胞膜重塑促进沙门氏菌的内吞，为抗感染治疗提供新靶点。
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注：以上文献为模拟内容，实际引用时请通过PubMed或Google Scholar搜索真实文献(关键词：RAB21 antibody, RAB21 function)。
**Background of RAB21 Antibody**
RAB21 is a member of the RAB family of small GTPases, which regulate membrane trafficking and vesicle transport in eukaryotic cells. Specifically, RAB21 is implicated in endosomal sorting, autophagy, integrin trafficking, and cell migration. It cycles between an active GTP-bound state and an inactive GDP-bound state, interacting with effector proteins to coordinate intracellular cargo transport. Dysregulation of RAB21 has been linked to pathologies such as cancer, neurodegenerative disorders, and immune dysfunctions, highlighting its biological relevance.
RAB21 antibodies are essential tools for studying its expression, localization, and function. These antibodies are typically developed using immunogens derived from conserved regions of the RAB21 protein and validated for specificity in applications like Western blotting, immunofluorescence, and immunohistochemistry. Researchers employ RAB21 antibodies to investigate its role in cellular processes, such as receptor recycling or pathogen invasion mechanisms, and to explore its potential as a biomarker or therapeutic target. Commercial RAB21 antibodies often target epitopes in human or model organisms (e.g., mouse, rat), ensuring cross-species compatibility in experimental models. Recent studies also utilize these antibodies to dissect RAB21’s interplay with other RAB GTPases and its impact on disease pathways, underscoring its growing significance in cell biology and translational research.
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