| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, 312-, Thioesterase superfamily member 2, Acyl-coenzyme A thioesterase 13, N-terminally processed, ACOT13, THEM2 |
| Entrez GeneID | 55856 |
| WB Predicted band size | 15.0kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This THEM2 monoclonal antibody is generated from mouse immunized with THEM2 recombinant protein. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是3篇与THEM2抗体相关的虚构参考文献示例，结构符合您的要求：
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1. **文献名称**: "THEM2 modulates hepatic lipid metabolism through acyl-CoA thioesterase activity"
**作者**: Chen L, et al.
**摘要**: 本研究利用THEM2特异性抗体，揭示了THEM2通过水解长链脂肪酸-CoA酯调控肝脏脂质代谢的机制。实验表明，THEM2缺失小鼠出现脂肪肝表型，抗体染色显示其在线粒体的定位，提示其在非酒精性脂肪肝中的潜在作用靶点。
2. **文献名称**: "Development of a monoclonal antibody against THEM2 for cancer biomarker studies"
**作者**: Kim S, et al.
**摘要**: 文章报道了一种高特异性抗THEM2单克隆抗体的制备，并验证其在人肝癌组织中的检测灵敏度。通过免疫组化分析，发现THEM2在肝癌细胞中显著高表达，且与患者预后不良相关，提示其作为肿瘤生物标志物的潜力。
3. **文献名称**: "THEM2 regulates mitochondrial β-oxidation via protein-protein interaction networks"
**作者**: Gupta R, et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合THEM2抗体，本研究鉴定了THEM2与CPT1A等脂肪酸氧化关键酶的相互作用。敲低实验证实THEM2通过调控线粒体β-氧化影响细胞能量代谢，为代谢综合征治疗提供新方向。
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注：以上文献为模拟示例，实际研究中请通过PubMed或Web of Science以关键词“THEM2 antibody”或“THEM2 thioesterase”检索真实文献。如需具体文献推荐，可进一步说明研究场景。
THEM2 (Thioesterase Superfamily Member 2), also known as ACOT13. is a mitochondrial enzyme involved in lipid metabolism, particularly fatty acid metabolism. It hydrolyzes fatty acyl-CoA thioesters into free fatty acids and CoA, regulating intracellular lipid transport and energy homeostasis. THEM2 is highly expressed in metabolically active tissues like the liver, heart, and adipose tissue. Studies link it to metabolic disorders, including obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), due to its role in balancing lipid storage and oxidation.
THEM2 antibodies are critical tools for studying its expression, localization, and function. They enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research on THEM2's interaction with lipid carriers (e.g., FABP1) and metabolic pathways (e.g., PPARα signaling). Recent work explores THEM2 as a potential therapeutic target, with antibodies used to validate its role in disease models. However, its regulatory mechanisms and tissue-specific functions remain under investigation. Developing specific, high-affinity THEM2 antibodies continues to advance understanding of its contribution to metabolic dysregulation and therapeutic opportunities.
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