关键信息
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基因名
GRID2
- 应用
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别名
delta-2; GluD2; GLUR D2; GluR delta 2; GluR delta-2 subunit; GLURD 2; GLURD2; Glutamate receptor delta 2 subunit ; Glutamate receptor ionotropic; Glutamate receptor ionotropic delta 2; GRID 2; Grid2; GRID2_HUMAN; MGC117022; MGC117023; MGC117024
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43424
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表达区间
908-1007aa
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氨基酸序列
DTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The study of GRID2, or Glutamate Receptor Interacting Protein 2, has garnered significant attention in the neuroscience and molecular biology fields due to its critical role in synaptic transmission and plasticity. GRID2 is primarily expressed in the brain, where it interacts with the ionotropic glutamate receptors, particularly the delta and AMPA receptor subtypes. Research has indicated that GRID2 is essential for the proper localization of these receptors at synapses, influencing their trafficking and function. Dysregulation of GRID2 has been implicated in various neurological disorders, including autism spectrum disorders, intellectual disabilities, and other cognitive impairments. The reconstitution of GRID2 protein has become a focal point for elucidating its molecular mechanisms and physiological functions. By producing recombinant GRID2, researchers aim to investigate its interactions with various proteins, its role in receptor signaling pathways, and its contribution to synaptic architecture. This understanding could pave the way for novel therapeutic strategies targeting GRID2-associated pathologies. Ultimately, studies on GRID2 proteins not only enhance our comprehension of fundamental synaptic processes but also hold promise for addressing disorders linked to glutamatergic signaling disruptions.
