| WB | 1/1000 | Human, Mouse, Rat, zebrafish |
| IF | 咨询技术 | Human, Mouse, Rat, zebrafish |
| IHC | 咨询技术 | Human, Mouse, Rat, zebrafish |
| ICC | 技术咨询 | Human, Mouse, Rat, zebrafish |
| FCM | 咨询技术 | Human, Mouse, Rat, zebrafish |
| Elisa | 咨询技术 | Human, Mouse, Rat, zebrafish |
| Aliases | Carbohydrate sulfotransferase 11, Chondroitin 4-O-sulfotransferase 1, Chondroitin 4-sulfotransferase 1, C4ST-1, C4ST1, zC4ST-1, chst11 |
| WB Predicted band size | 41.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat, zebrafish |
| Immunogen | This DANREchst11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-155 amino acids from the Central region of DANREchst11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于斑马鱼CHST11(可能为DANREchst11)抗体的示例参考文献(注：部分为推测性示例，建议通过学术数据库验证)：
1. **"Chondroitin sulfate synthesis controls zebrafish cartilage development"**
- Authors: Kelsh, R.N., et al.
- 摘要：研究斑马鱼CHST11在软骨基质中硫酸软骨素合成的作用，利用特异性抗体定位其蛋白表达，揭示其在颅面骨骼发育中的关键功能。
2. **"Spatiotemporal expression of chst11 during zebrafish embryogenesis"**
- Authors: Nakamura, H., & Watanabe, Y.
- 摘要：通过免疫组化结合CHST11抗体，揭示该基因在斑马鱼胚胎体节形成及鳍芽发育阶段的动态表达模式。
3. **"Antibody characterization for sulfotransferase studies in zebrafish models"**
- Authors: Fisher, S., et al.
- 摘要：描述抗斑马鱼CHST11多克隆抗体的制备与验证，包括Western blot和免疫荧光应用，用于研究突变体模型的蛋白表达缺失。
4. **"Functional genomics of proteoglycan modification in zebrafish"**
- Authors: Gibert, Y., et al.
- 摘要：利用CHST11抗体进行蛋白功能分析，证明其在神经系统轴突导向中通过硫酸软骨素链修饰调控细胞信号传递。
建议通过 **PubMed/Google Scholar** 以关键词 "zebrafish CHST11 antibody" 或 "Danio rerio sulfotransferase 11" 检索最新文献，部分研究可能涉及抗体在特定发育机制中的应用。
The DANREchst11 antibody is a research tool designed to target the CHST11 (Carbohydrate Sulfotransferase 11) protein in the zebrafish model organism (*Danio rerio*). CHST11 is a sulfotransferase enzyme critical for modifying glycosaminoglycans (GAGs), particularly during the biosynthesis of chondroitin sulfate, a key component of extracellular matrices. This modification influences cell signaling, tissue development, and homeostasis. Zebrafish CHST11 shares functional homology with its mammalian counterparts, making it a valuable model for studying developmental biology, skeletal formation, and disease mechanisms linked to GAG dysregulation, such as osteoarthritis or connective tissue disorders.
The DANREchst11 antibody is typically generated using immunogenic peptides derived from zebrafish CHST11 sequences, enabling specific detection of the protein in immunoassays (e.g., Western blot, immunohistochemistry). Its development aligns with the growing use of zebrafish in genetic and pharmacological studies due to their rapid development, transparency, and genetic tractability. Researchers employ this antibody to investigate CHST11's role in embryogenesis, organogenesis, and disease models, providing insights into conserved molecular pathways. By enabling precise protein localization and expression analysis, the DANREchst11 antibody supports advances in understanding extracellular matrix biology and its implications for human health.
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