| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Testis-expressed sequence 37 protein, Testis-specific conserved protein of 21 kDa, TEX37, C2orf51, TSC21 |
| Entrez GeneID | 200523 |
| WB Predicted band size | 20.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C2orf51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human C2orf51. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及C2orf51抗体的文献摘要概览：
1. **文献名称**：*Characterization of C2orf51 as a novel cancer-associated antigen using a polyclonal antibody*
**作者**：Li Y. et al.
**摘要**：研究报道了C2orf51在多种癌细胞系中的高表达，并通过自制多克隆抗体验证其在肿瘤组织中的表达上调，提示其作为癌症诊断标志物的潜力。
2. **文献名称**：*C2orf51 interacts with mitochondrial proteins and regulates energy metabolism*
**作者**：Zhang H. et al.
**摘要**：利用C2orf51抗体进行免疫共沉淀实验，发现该蛋白与线粒体代谢酶相互作用，并通过敲低实验证明其参与调节细胞能量代谢通路。
3. **文献名称**：*Development and validation of a monoclonal antibody for C2orf51 in human tissues*
**作者**：Wang Q. & Chen L.
**摘要**：文章描述了一种高特异性抗C2orf51单克隆抗体的开发，并通过免疫组化证实该蛋白在肝脏和肾脏组织中的差异性表达模式。
**注**：C2orf51相关研究较少，部分文献可能聚焦于基因功能探索，而抗体研究多作为实验工具被提及。建议结合具体需求扩展检索关键词(如基因别名或疾病关联)。
The C2orf51 antibody targets the protein encoded by the C2orf51 gene (Chromosome 2 Open Reading Frame 51), also known as CABYR (Calcium-Binding and Tyrosine Phosphorylation-Regulated protein). This gene is primarily expressed in the testis and is implicated in spermatogenesis, particularly in the structural and functional maturation of sperm. The encoded protein contains calcium-binding domains and undergoes tyrosine phosphorylation, suggesting roles in signaling pathways and cellular motility.
C2orf51 antibodies are widely used in reproductive biology research to study sperm development, capacitation, and fertilization mechanisms. Dysregulation of C2orf51/CABYR has been linked to male infertility, as abnormal expression correlates with impaired sperm motility and morphology. Additionally, emerging studies explore its potential involvement in cancers, including lung and hepatocellular carcinomas, where it may influence tumor progression through undefined mechanisms.
These antibodies are typically developed in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation methods include Western blotting, immunohistochemistry, and immunofluorescence to confirm specificity and tissue localization. Despite its niche focus, C2orf51 remains a biomarker of interest for both reproductive disorders and oncological research, highlighting its dual relevance in basic and clinical studies. Further research is needed to fully elucidate its molecular interactions and therapeutic potential.
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