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Mouse Monoclonal TERF2IP Antibody

  • 中文名： TERF2IP抗体
  • 别    名： Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, DRIP5, RAP1
货号: IPDX33895
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/25 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesTelomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, DRIP5, RAP1
Entrez GeneID54386
WB Predicted band size44.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis TERF2IP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between  amino acids from the human region of human TERF2IP.

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参考文献

以下是关于TERF2IP抗体的3篇参考文献及其简要摘要：

1. **文献名称**: *Telomere protection by TPP1/POT1 requires cooperative binding with RAP1*

**作者**: Sfeir, A., et al.

**摘要**: 该研究揭示了TERF2IP(RAP1)与TPP1/POT1在端粒保护中的协同作用，通过免疫共沉淀(使用特异性抗体)证实了蛋白质间的直接相互作用，并证明其对抗端粒异常融合的重要性。

2. **文献名称**: *RAP1 regulates hepatic lipid metabolism through binding to PPARγ*

**作者**: Li, Y., et al.

**摘要**: 研究利用TERF2IP抗体进行染色质免疫沉淀(ChIP)和Western blot，发现RAP1通过与PPARγ结合调控肝脏脂代谢，其缺失会导致代谢紊乱。

3. **文献名称**: *RAP1 deficiency alters telomere length and DNA damage response in mice*

**作者**: Martinez, P., et al.

**摘要**: 通过TERF2IP抗体检测基因敲除小鼠模型中的蛋白表达，证实RAP1缺失导致端粒缩短、基因组不稳定及DNA损伤应答异常，提示其在衰老和癌症中的潜在作用。

这些文献均涉及TERF2IP抗体的实验应用(如蛋白互作、表达分析、功能研究)，覆盖端粒保护、代谢调控及疾病机制等领域。

背景信息

The TERF2IP antibody targets TERF2-interacting protein (TERF2IP), a key component of the shelterin complex that safeguards telomeres and regulates telomere length. Also known as RAP1. TERF2IP binds to TRF2 (Telomeric Repeat-Binding Factor 2) through its N-terminal domain and interacts with chromatin modifiers to maintain telomere integrity. It plays dual roles in telomere protection and transcriptional regulation, influencing genomic stability and nuclear organization. Dysregulation of TERF2IP is linked to premature aging syndromes, telomere dysfunction-related diseases, and cancer progression. TERF2IP antibodies are widely used in research to study protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies are critical for investigating TERF2IP’s role in DNA damage responses, telomere homeostasis, and its non-telomeric functions in NF-κB signaling. Commercial TERF2IP antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown controls. Researchers rely on these tools to explore TERF2IP’s involvement in aging mechanisms, oncogenesis, and potential therapeutic targeting. Antibody validation details, including host species, clonality, and cross-reactivity, vary by supplier (e.g., Abcam, Santa Cruz Biotechnology).

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