| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pre-mRNA-splicing factor 38A, PRPF38A |
| Entrez GeneID | 84950 |
| WB Predicted band size | 37.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PR38A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human PR38A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PR38A (C-term)抗体的示例参考文献(内容为虚构，仅用于示例)：
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1. **"Characterization of PR38A in Cell Cycle Regulation"**
*Author: Lee et al. (2018)*
*摘要*：本研究利用PR38A (C-term)抗体，通过Western blot和免疫荧光技术，发现PR38A在G1/S期转换中调控CDK2活性，并揭示其C端结构域与磷酸化修饰相关。
2. **"PR38A Interaction with Tumor Suppressor p53"**
*Author: Martinez et al. (2020)*
*摘要*：通过免疫共沉淀(Co-IP)实验，使用PR38A (C-term)抗体验证了PR38A与p53的直接结合，表明其在DNA损伤应答中可能作为辅因子参与p53稳定性调控。
3. **"PR38A Expression in Neurodegenerative Disease Models"**
*Author: Chen & Park (2021)*
*摘要*：采用PR38A (C-term)抗体进行组织染色，发现PR38A在阿尔茨海默病小鼠模型中表达上调，并与tau蛋白异常聚集相关，提示其潜在病理作用。
4. **"Structural Analysis of PR38A C-terminal Domain"**
*Author: Gupta et al. (2019)*
*摘要*：结合X射线晶体学和PR38A (C-term)抗体验证，揭示了PR38A C端结构域的α-螺旋构象及其在核质转运中的关键功能。
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注：以上文献为模拟示例，实际研究中请根据具体实验需求查询真实数据库(如PubMed、Google Scholar)。
The PR38A (C-term) antibody is a polyclonal or monoclonal antibody specifically designed to recognize the C-terminal region of a target protein, often denoted as "PR38A." While the exact identity of the PR38A protein may vary depending on the research context, such antibodies are typically developed to study proteins involved in critical cellular processes, such as signal transduction, apoptosis, or cell cycle regulation. The C-terminal region is frequently targeted due to its functional significance, as it may contain conserved domains, post-translational modification sites (e.g., phosphorylation), or binding motifs essential for protein-protein interactions.
PR38A (C-term) antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect endogenous expression levels, subcellular localization, or protein complexes. Their specificity is validated through knockout/knockdown controls or peptide-blocking assays to ensure minimal cross-reactivity. These antibodies are valuable tools in research areas such as cancer biology, neurobiology, or immunology, where understanding the role of PR38A in disease mechanisms or normal physiology is critical.
Commercial sources often provide detailed datasheets outlining immunogen sequences, host species (e.g., rabbit, mouse), and recommended applications. Researchers should verify species reactivity (e.g., human, mouse, rat) and optimize experimental conditions (e.g., dilution, buffer) for reproducibility.
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