Rabbit Polyclonal HBA2 Antibody

The HBA2 antibody targets the α2-globin subunit of hemoglobin, a critical oxygen-transport protein in red blood cells. Encoded by the *HBA2* gene, α2-globin combines with β-globin to form adult hemoglobin (HbA, α2β2), which facilitates oxygen delivery throughout the body. Mutations in *HBA2* are linked to α-thalassemia, a genetic disorder characterized by reduced α-globin synthesis, leading to anemia and related complications. HBA2 antibodies are essential tools in hematology research, enabling detection and quantification of α2-globin expression in studies of hemoglobinopathies. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein distribution, diagnose thalassemia variants, and monitor therapeutic interventions. Additionally, these antibodies aid in differentiating α-thalassemia from other anemias by identifying specific α-globin deficiencies. Commercial HBA2 antibodies are typically raised in hosts such as rabbits or mice, validated for specificity to avoid cross-reactivity with homologous proteins like HBA1. Recent research also explores their utility in gene therapy and CRISPR-based editing approaches aimed at correcting *HBA2* mutations. By advancing understanding of α-globin biology and pathology, HBA2 antibodies contribute to both basic science and clinical diagnostics, supporting efforts to develop targeted treatments for hemoglobin-related disorders.