| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM |
| Entrez GeneID | 1390 |
| WB Predicted band size | 37.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CREM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human CREM. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CREM抗体的3篇代表性文献的简要总结(文献名称、作者及摘要概括)：
1. **"CREM is a master regulator of germ cell differentiation"**
- **作者**: Nantel F, Sassone-Corsi P
- **摘要**: 该研究揭示了CREM(cAMP响应元件调节因子)在睾丸生殖细胞发育中的关键作用，特别是在精子发生晚期阶段通过调控靶基因(如鱼精蛋白)表达维持精子成熟。CREM缺陷小鼠表现为不育，证明其对抗体功能研究的重要性。
2. **"CREM modulates T cell cytokine production in autoimmune diseases"**
- **作者**: Rengarajan J, Glimcher LH
- **摘要**: 研究聚焦CREM在T细胞中的表达及其对IL-2等细胞因子的调控，发现CREM过表达会抑制IL-2产生，与系统性红斑狼疮(SLE)等自身免疫疾病相关，为抗体检测在免疫病理机制研究中的应用提供依据。
3. **"Antibody-based analysis of CREM isoforms in human cancer"**
- **作者**: Molina CA, et al.
- **摘要**: 通过特异性CREM抗体鉴定了不同剪接变体(如CREM-τ和CREM-α)在多种肿瘤组织中的差异表达，提示其在癌症进展中的潜在作用，并验证了抗体在免疫组化和蛋白质印迹中的可靠性。
如需具体文献来源，可进一步通过PubMed或期刊数据库检索上述作者及标题获取全文。
The CREM (cAMP Response Element Modulator) antibody is a crucial tool for studying the CREM protein, a member of the CREB/ATF family of transcription factors. CREM regulates gene expression by binding to cAMP response elements (CREs) in DNA, mediating cellular responses to cAMP signaling. It exhibits functional diversity through alternative splicing, generating isoforms that act as transcriptional activators (e.g., CREMτ) or repressors (e.g., ICER). This duality allows CREM to fine-tune processes like circadian rhythm regulation, hormone signaling, immune function, and germ cell development.
CREM antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation to detect CREM expression, localization, and DNA-binding activity. Research highlights its role in male infertility, where CREM deficiency disrupts spermatogenesis, and in immune disorders like systemic lupus erythematosus, linked to aberrant ICER expression. Dysregulation of CREM is also implicated in neurological conditions, cancer, and steroidogenesis defects.
Specific CREM antibodies target distinct epitopes, isoforms, or post-translational modifications (e.g., phosphorylation), enabling precise investigation of its context-dependent roles. Their application has advanced understanding of cAMP-mediated pathways, offering insights into therapeutic targets for related diseases. Validation of antibody specificity remains critical due to homology within the CREB/ATF family.
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