| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 60S ribosomal protein L18a, RPL18A |
| Entrez GeneID | 6142 |
| WB Predicted band size | 20.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RPL18A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-166 amino acids from the C-terminal region of human RPL18A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于RPL18A抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**: *"RPL18A Antibody Validation in Ribosomal Protein Profiling"*
**作者**: Johnson, M. et al. (2017)
**摘要**: 该研究验证了RPL18A抗体的特异性，通过Western blot和免疫荧光技术确认其在多种哺乳动物细胞系中的适用性，并成功应用于核糖体分离实验中的蛋白质定位分析。
2. **文献名称**: *"RPL18A Interacts with Viral RNA in Influenza A Infection"*
**作者**: Lee, S. et al. (2019)
**摘要**: 利用RPL18A抗体进行免疫共沉淀实验，发现RPL18A与甲型流感病毒RNA结合，抑制其表达可显著降低病毒复制效率，提示其在宿主-病毒相互作用中的潜在角色。
3. **文献名称**: *"Overexpression of RPL18A in Glioblastoma: A Prognostic Marker Study"*
**作者**: Smith, J. et al. (2020)
**摘要**: 通过免疫组化(使用RPL18A抗体)分析胶质母细胞瘤组织，发现RPL18A高表达与肿瘤侵袭性和患者生存率降低相关，表明其作为预后生物标志物的可能性。
---
**注**：以上文献为假设性示例，实际引用需查询PubMed、Google Scholar等数据库获取真实文献。若需具体文献检索方法，可进一步说明。
The ribosomal protein L18a (RPL18A) is a component of the 60S ribosomal subunit, playing a critical role in ribosome biogenesis and protein synthesis. As part of the large ribosomal subunit, RPL18A contributes to the structural stability of the ribosome and facilitates interactions with rRNA and other ribosomal proteins during translation. It is encoded by the RPL18A gene in humans and is highly conserved across eukaryotes, underscoring its essential role in cellular function. Dysregulation of RPL18A has been implicated in various diseases, including cancers, where its overexpression may correlate with tumor progression and poor prognosis, potentially due to enhanced ribosome production supporting rapid cell proliferation.
RPL18A antibodies are immunological tools used to detect and study the expression, localization, and function of the RPL18A protein. These antibodies, often generated in rabbits or mice, are validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. Researchers employ RPL18A antibodies to investigate ribosome dynamics, translational regulation, and cellular stress responses. In disease contexts, they help explore connections between ribosomal dysfunction and pathologies like cancer, neurodegeneration, or viral infections, where ribosome hijacking may occur. Specificity and reliability of RPL18A antibodies are confirmed using knockout controls or siRNA knockdowns, ensuring accurate interpretation in experimental models. Their utility extends to both basic research and clinical studies aiming to identify biomarkers or therapeutic targets linked to ribosomal activity.
×
