| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-muscle, Cytochrome c oxidase subunit VIIa-M, COX7A1, COX7AH |
| Entrez GeneID | 1346 |
| WB Predicted band size | 9.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This COX7A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-38 amino acids from the Central region of human COX7A1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于COX7A1抗体的示例参考文献(内容为虚构示例，仅作格式参考)：
1. **文献名称**: "Differential Expression of COX7A1 in Human Cancers: Implications for Mitochondrial Metabolism"
**作者**: Smith J, et al.
**摘要**: 本研究通过免疫组化和Western blot技术，使用COX7A1抗体分析其在多种肿瘤组织中的表达水平，发现COX7A1低表达与线粒体功能异常及患者预后不良相关。
2. **文献名称**: "COX7A1 Antibody Validation in Murine Models of Cardiac Ischemia"
**作者**: Lee S, et al.
**摘要**: 验证COX7A1抗体在小鼠心肌缺血模型中的应用，证实其在心脏组织中线粒体复合物IV的定位，并揭示其表达变化与氧化应激损伤的关联。
3. **文献名称**: "COX7A1 as a Novel Biomarker in Neurodegenerative Disorders: An Antibody-Based Study"
**作者**: Garcia R, et al.
**摘要**: 利用COX7A1抗体检测阿尔茨海默病患者脑脊液样本，发现其表达水平与线粒体功能障碍程度呈负相关，提示其潜在诊断价值。
4. **文献名称**: "Functional Characterization of COX7A1 in Zebrafish Using Specific Polyclonal Antibodies"
**作者**: Wang X, et al.
**摘要**: 通过COX7A1多克隆抗体研究斑马鱼模型中线粒体呼吸链组装缺陷，揭示该基因在胚胎发育中的关键作用。
(注：以上文献为示例，非真实存在，实际引用需查询权威数据库如PubMed、Web of Science等。)
The COX7A1 antibody is a valuable tool for studying the expression and function of cytochrome c oxidase subunit 7A1 (COX7A1), a nuclear-encoded component of mitochondrial respiratory chain Complex IV (cytochrome c oxidase). As part of the terminal enzyme in the electron transport chain, COX7A1 contributes to oxidative phosphorylation by facilitating the transfer of electrons to oxygen, coupled with proton pumping across the mitochondrial inner membrane. This subunit exists in two tissue-specific isoforms (COX7A1 and COX7A2), with COX7A1 predominantly expressed in the liver, kidney, and heart.
COX7A1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate mitochondrial dysfunction, metabolic disorders, and diseases linked to oxidative phosphorylation defects, such as neurodegenerative conditions, cardiomyopathies, and cancer. Researchers utilize these antibodies to assess COX7A1 protein levels, subcellular localization, and tissue-specific expression patterns. Many commercially available COX7A1 antibodies are raised against conserved epitopes, enabling cross-reactivity in human, mouse, and rat models. Validation typically includes knockdown controls or mitochondrial fractionation to confirm specificity. Studies employing COX7A1 antibodies have provided insights into cellular energy metabolism regulation and its perturbation in pathological states, making them essential for mitochondrial biology and metabolic disease research.
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