| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein kinase C gamma type, PKC-gamma, Prkcg, Pkcc, Pkcg, Prkcc |
| Entrez GeneID | 18752 |
| WB Predicted band size | 78.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Prkcg antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-102 amino acids from the N-terminal region of mouse Prkcg. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Prkcg (N-term)抗体的3篇参考文献示例：
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1. **文献名称**: *Protein Kinase C gamma (Prkcg) Expression in Cerebellar Purkinje Cells: Role in Synaptic Plasticity*
**作者**: Yamamoto H, et al.
**摘要**: 本研究使用N端特异性抗体验证小鼠小脑浦肯野细胞中Prkcg的表达，证实其通过调节突触蛋白磷酸化参与运动学习。抗体通过Western blot和免疫组化验证特异性。
2. **文献名称**: *Characterization of Prkcg Knockout Mice Using N-terminal Antibody*
**作者**: Chen L, et al.
**摘要**: 通过N端靶向抗体分析Prkcg基因敲除小鼠模型，发现蛋白表达完全缺失，揭示Prkcg在神经退行性疾病中的保护作用。抗体特异性经HEK293细胞过表达实验验证。
3. **文献名称**: *Role of PKCγ in Inflammatory Pain Signaling: Insights from Antibody-based Localization*
**作者**: Martinez R, et al.
**摘要**: 利用Prkcg (N-term)抗体定位小鼠脊髓背角神经元中的PKCγ，证明其在炎症性疼痛中激活TRPV1通道，抗体特异性通过siRNA敲降实验确认。
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**注**：以上文献为示例，实际引用需根据具体研究补充。建议通过抗体供应商(如Abcam、CST)官网或PubMed检索相关验证数据。
**Background of the Mouse Prkcg (N-term) Antibody**
The Mouse Prkcg (N-term) antibody is a monoclonal antibody specifically designed to target the N-terminal region of protein kinase C gamma (PKCγ), encoded by the *PRKCG* gene. PKCγ is a member of the protein kinase C (PKC) family of serine/threonine kinases, which play critical roles in signal transduction pathways regulating cell proliferation, differentiation, apoptosis, and synaptic plasticity.
PKCγ is predominantly expressed in the central nervous system, particularly in cerebellar Purkinje cells, and is implicated in neuronal development, learning, and motor coordination. Dysregulation of PKCγ has been linked to neurodegenerative disorders, including spinocerebellar ataxia type 14 (SCA14), a condition characterized by progressive motor dysfunction.
The Mouse Prkcg (N-term) antibody is widely used in research to detect and quantify PKCγ expression in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length or truncated forms of the protein, aiding studies on PKCγ’s structural and functional roles.
This antibody is particularly valuable in investigating PKCγ’s involvement in neurological diseases, synaptic signaling, and its interaction with calcium and phospholipids. By enabling precise detection, it supports mechanistic insights into PKCγ-related pathways and potential therapeutic targets.
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