| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclin-dependent kinase 13, CDC2-related protein kinase 5, Cell division cycle 2-like protein kinase 5, Cell division protein kinase 13, Cdk13, Cdc2l5, Kiaa1791 |
| Entrez GeneID | 69562 |
| WB Predicted band size | 164.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Cdk13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the N-terminal region of mouse Cdk13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Cdk13 (N-term)抗体的示例参考文献(注：以下内容为虚构示例，仅用于演示格式)：
1. **"Cdk13 Kinase Activity in Mouse Embryonic Development"**
- **作者**: Zhang et al. (2020)
- **摘要**: 研究使用针对Cdk13 N端的特异性抗体，通过免疫印迹和免疫组化分析Cdk13在小鼠胚胎不同发育阶段的表达及功能，揭示其参与胚胎神经管闭合和器官形成。
2. **"Cdk13 Regulates Transcriptional Elongation in Mouse Stem Cells"**
- **作者**: Lee et al. (2018)
- **摘要**: 利用N端Cdk13抗体进行染色质免疫沉淀(ChIP)，证明Cdk13与RNA聚合酶II结合，调控小鼠胚胎干细胞的转录延伸过程，影响多能性基因表达。
3. **"Characterization of Cdk13 Knockout Mouse Phenotypes"**
- **作者**: Smith et al. (2019)
- **摘要**: 通过Western blot(使用Cdk13 N-term抗体验证基因敲除效率)和表型分析，发现Cdk13缺失导致小鼠胚胎致死，并扰乱心脏发育相关信号通路。
4. **"Cdk13 Interaction with Cyclin K in Mouse Cell Cycle Progression"**
- **作者**: Garcia et al. (2021)
- **摘要**: 采用N端特异性抗体进行免疫共沉淀(Co-IP)，证明Cdk13与Cyclin K在小鼠成纤维细胞中形成复合物，调控G1/S期转换和细胞增殖。
建议通过**PubMed**或**Google Scholar**以关键词“Mouse Cdk13 N-term antibody”或“Cdk13 N-terminal epitope”检索真实文献，并筛选实验方法部分明确使用该抗体的研究。
The Mouse Cdk13 (N-term) antibody is designed to specifically target the N-terminal region of cyclin-dependent kinase 13 (CDK13) in mouse-derived samples. CDK13. a member of the CDK family, plays a critical role in transcriptional regulation by phosphorylating the C-terminal domain of RNA polymerase II, facilitating transcriptional elongation, mRNA processing, and chromatin remodeling. Its N-terminal domain is essential for interactions with regulatory cyclin partners and other cofactors, influencing cell cycle progression, differentiation, and developmental processes. Dysregulation of CDK13 has been implicated in cancers and neurodevelopmental disorders.
This antibody is commonly used in applications like Western blotting, immunofluorescence, and immunoprecipitation to study CDK13 expression, localization, and function in murine models. By detecting endogenous CDK13. it aids in exploring its role in disease mechanisms or genetic pathways. Validation typically includes testing on knockout controls to confirm specificity. Researchers employ this tool to investigate CDK13's involvement in transcriptional dynamics, cell cycle checkpoints, and its potential as a therapeutic target. The N-term specificity ensures recognition of full-length or truncated isoforms, depending on epitope conservation.
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