Rabbit Polyclonal RPS24 Antibody

The RPS24 antibody targets the ribosomal protein S24. a component of the 40S ribosomal subunit involved in mRNA translation and ribosome biogenesis. RPS24 is encoded by the RPS24 gene in humans and plays a critical role in assembling the small ribosomal subunit and maintaining translational fidelity. Dysregulation of RPS24 has been linked to ribosomal stress, impaired protein synthesis, and diseases such as Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure disorder caused by mutations in ribosomal protein genes. Research using RPS24 antibodies has helped elucidate its cellular localization (primarily nucleolar and cytoplasmic), expression patterns, and interactions with other ribosomal components. These antibodies are widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ribosome dynamics, cellular stress responses, and pathological mechanisms in DBA or cancer models. Additionally, RPS24 antibodies serve as tools to investigate potential therapeutic targets for disorders linked to ribosomal dysfunction. Recent studies also explore its role in tumorigenesis, as altered ribosomal protein expression may influence oncogenic pathways or chemotherapy resistance.