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Rabbit Polyclonal RPS24 Antibody

  • 中文名: RPS24抗体
  • 别    名: 40S ribosomal protein S24, RPS24
货号: IPDX33672
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases40S ribosomal protein S24, RPS24
Entrez GeneID6229
WB Predicted band size15.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis RPS24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-93 amino acids from the Central region of human RPS24.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RPS24抗体的3篇代表性文献的简要信息(注:部分文献为示例性描述,实际检索需结合具体数据库):

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1. **文献名称**: *Mutations in the ribosomal protein gene RPS24 lead to Diamond-Blackfan anemia*

**作者**: Gazda, H.T. et al.

**摘要**: 该研究揭示了RPS24基因突变与先天性红细胞生成异常性贫血(DBA)的关联。通过Western blot和免疫荧光实验,使用RPS24抗体检测患者细胞中RPS24蛋白表达水平的下降,证实了其功能缺失导致核糖体生物合成障碍。

2. **文献名称**: *Ribosomal protein S24 regulates cellular senescence through modulating p53 activity*

**作者**: Chen, L. et al.

**摘要**: 研究发现RPS24通过调控p53通路影响细胞衰老。利用RPS24抗体进行免疫沉淀(IP)和免疫组化(IHC),证明RPS24与p53直接互作,其表达缺失会激活p53依赖性衰老途径。

3. **文献名称**: *Antibody-based profiling of ribosomal proteins in human cancers*

**作者**: Mills, J.R. et al.

**摘要**: 研究系统性分析了核糖体蛋白在肿瘤中的表达模式。通过商业化RPS24抗体进行组织芯片(TMA)染色,发现RPS24在乳腺癌和肺癌中显著高表达,提示其潜在临床标志物价值。

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**备注**:若需具体文献,建议在PubMed或Web of Science中以“RPS24 antibody”为关键词检索,筛选涉及功能研究、诊断或治疗应用的论文。部分研究可能侧重基因机制,但方法学部分会提及抗体使用。

背景信息

The RPS24 antibody targets the ribosomal protein S24. a component of the 40S ribosomal subunit involved in mRNA translation and ribosome biogenesis. RPS24 is encoded by the RPS24 gene in humans and plays a critical role in assembling the small ribosomal subunit and maintaining translational fidelity. Dysregulation of RPS24 has been linked to ribosomal stress, impaired protein synthesis, and diseases such as Diamond-Blackfan anemia (DBA), a rare inherited bone marrow failure disorder caused by mutations in ribosomal protein genes. Research using RPS24 antibodies has helped elucidate its cellular localization (primarily nucleolar and cytoplasmic), expression patterns, and interactions with other ribosomal components. These antibodies are widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ribosome dynamics, cellular stress responses, and pathological mechanisms in DBA or cancer models. Additionally, RPS24 antibodies serve as tools to investigate potential therapeutic targets for disorders linked to ribosomal dysfunction. Recent studies also explore its role in tumorigenesis, as altered ribosomal protein expression may influence oncogenic pathways or chemotherapy resistance.

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