Rabbit Polyclonal TBK1(S172) Antibody

The TBK1 (S172) antibody is a crucial tool for studying the activation and function of TANK-binding kinase 1 (TBK1), a serine/threonine kinase central to innate immunity, autophagy, and inflammatory signaling. TBK1 phosphorylates downstream targets like IRF3 and NF-κB to regulate antiviral responses and cytokine production. The S172 phosphorylation site (Serine 172) within the kinase domain is critical for TBK1 activation, as autophosphorylation at this residue enhances its enzymatic activity and facilitates interactions with adaptor proteins. Antibodies specific to phosphorylated S172 (pS172) enable researchers to detect TBK1 activation status in various experimental settings, such as Western blotting, immunofluorescence, or immunoprecipitation. These antibodies are widely used to investigate signaling pathways triggered by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), including STING, RIG-I, and TLR pathways. Dysregulation of TBK1 activity is linked to autoimmune diseases, neurodegenerative disorders (e.g., ALS), and cancer, making this antibody valuable for both basic research and translational studies. Specificity validation via knockout/knockdown controls or phosphatase treatment is recommended to confirm accurate detection of phosphorylated TBK1.