| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tubulin beta-1 chain, TUBB1 |
| Entrez GeneID | 81027 |
| WB Predicted band size | 50.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TBB1 antibody is generated from rabbits immunized with human TBB1 recombinant protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBB1(β-tubulin)抗体的虚构参考文献示例(仅作格式参考，非真实文献)：
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1. **文献名称**: "β-Tubulin as a Reliable Loading Control in Western Blot Analysis"
**作者**: Smith J, et al.
**摘要**: 本研究验证了TBB1抗体作为蛋白质印迹内参的稳定性，证明其在多种细胞系和组织样本(如肿瘤、脑组织)中表达量恒定，适用于不同实验条件下的数据标准化。
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2. **文献名称**: "TBB1 Overexpression Correlates with Chemoresistance in Colorectal Cancer"
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(TBB1抗体)分析结直肠癌组织样本，发现TBB1高表达与紫杉醇类药物耐药性显著相关，提示其可作为化疗疗效预测的生物标志物。
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3. **文献名称**: "Developmental Regulation of β-Tubulin Isoforms in Neuronal Differentiation"
**作者**: Gupta R, et al.
**摘要**: 利用TBB1特异性抗体研究神经元分化过程，发现TBB1在轴突形成早期阶段表达上调，而其他β-tubulin亚型(如TBB3)在成熟神经元中占主导，表明亚型功能分化。
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4. **文献名称**: "Comparative Evaluation of Commercial β-Tubulin Antibodies for Flow Cytometry"
**作者**: Kim S, et al.
**摘要**: 对比5种市售TBB1抗体的交叉反应性和灵敏度，发现克隆号AA2的抗体在流式细胞术中具有最优特异性，适用于淋巴细胞微管结构动态研究。
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注：以上内容为模拟生成，实际文献需通过PubMed/Google Scholar检索关键词(如"β-tubulin antibody application"或"TUBB1 biomarker")获取。
The TBB1 antibody targets beta-tubulin, a key component of microtubules essential for cellular structure, intracellular transport, and cell division. Beta-tubulin, encoded by the *TUBB* gene family, forms heterodimers with alpha-tubulin to assemble dynamic microtubule networks. As a housekeeping protein, beta-tubulin is widely expressed across tissues, making TBB1 antibodies valuable loading controls in Western blotting and normalization in immunoassays. These antibodies are also used to study microtubule dynamics in processes like mitosis, neuronal development, and cilia function.
TBB1 antibodies typically exhibit specificity for conserved epitopes in beta-tubulin isoforms, though cross-reactivity with closely related isoforms (e.g., TUBB2. TUBB3) may occur depending on the immunogen design. Commercial TBB1 antibodies are often validated in applications such as immunohistochemistry, flow cytometry, and immunofluorescence. Dysregulation of beta-tubulin expression or post-translational modifications has been linked to cancer, neurodegeneration, and drug resistance (e.g., taxane-based therapies). Researchers frequently employ TBB1 antibodies to explore disease mechanisms or assess tissue/cell integrity in experimental models. However, interpretation requires caution, as beta-tubulin levels may vary under certain stress conditions or in specialized cell types.
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