| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60 |
| Entrez GeneID | 10524 |
| WB Predicted band size | 58.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This KAT5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 367-398 amino acids from human KAT5. |
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以下是关于KAT5(TIP60)抗体的3篇示例文献(注：文献为假设性示例，建议通过学术数据库核实具体信息)：
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1. **文献名称**: *TIP60 acetyltransferase activity is essential for apoptosis in DNA damage response*
**作者**: Tang, Y. et al.
**摘要**: 本研究利用KAT5特异性抗体，通过Western blot和免疫沉淀技术，揭示了KAT5的乙酰化酶活性在DNA损伤诱导的细胞凋亡中的关键作用。实验表明，KAT5缺失会导致p53通路激活受阻。
2. **文献名称**: *A novel monoclonal antibody for KAT5 detection in breast cancer models*
**作者**: Wang, L. et al.
**摘要**: 作者开发了一种高特异性KAT5单克隆抗体，并验证其在乳腺癌组织中的灵敏度和特异性。该抗体成功用于免疫组化(IHC)分析，显示KAT5表达与肿瘤侵袭性呈负相关。
3. **文献名称**: *Chromatin remodeling by TIP60 requires direct interaction with histone H3 via its antibody-validated domains*
**作者**: Legube, G. et al.
**摘要**: 通过KAT5抗体的染色质免疫共沉淀(ChIP)实验，发现TIP60通过特定结构域与组蛋白H3结合，调控染色质重塑和DNA修复。研究强调了抗体在定位KAT5基因组靶点中的重要性。
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如需具体文献，建议在PubMed或Google Scholar中检索关键词“KAT5 antibody”或“TIP60 antibody”，并筛选应用类研究(如Western blot、ChIP等)。
The KAT5 antibody is a crucial tool for studying the KAT5 protein, also known as TIP60. a member of the MYST family of histone acetyltransferases (HATs). KAT5 plays a pivotal role in chromatin remodeling, DNA damage repair, transcriptional regulation, and apoptosis. It acetylates histone H4 and non-histone targets, facilitating the recruitment of repair proteins like ATM and BRCA1 to DNA double-strand breaks. Dysregulation of KAT5 is linked to cancers, neurodegenerative disorders, and aging, making it a focus in disease research.
KAT5 antibodies are widely used in techniques such as Western blotting, immunoprecipitation (IP), chromatin immunoprecipitation (ChIP), and immunofluorescence to detect protein expression, localization, and interactions. Specificity and validation are critical, as KAT5 shares structural motifs with other MYST family members. Researchers often verify antibodies using knockout cell lines or siRNA-mediated knockdown controls.
In cancer studies, KAT5 antibodies help explore its dual role as a tumor suppressor (via apoptosis induction) or oncogene (through pro-survival signaling). In neuroscience, they aid in investigating its involvement in tau acetylation and Alzheimer’s pathology. Therapeutic targeting of KAT5 in precision medicine is an emerging area, driving demand for reliable antibodies.
Overall, KAT5 antibodies are indispensable for unraveling the protein’s multifaceted functions and its potential as a biomarker or therapeutic target.
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