Rabbit Polyclonal FBXO33 Antibody

The FBXO33 antibody is a research tool designed to detect and study the F-box protein 33 (FBXO33), a member of the F-box protein family that functions as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. FBXO33 contains an F-box domain, which mediates interaction with SKP1. and a C-terminal domain hypothesized to recruit specific substrates for ubiquitination and subsequent proteasomal degradation. While the full biological role of FBXO33 remains under investigation, emerging studies suggest its involvement in critical cellular processes such as DNA damage response, cell cycle regulation, and epigenetic modulation. Dysregulation of FBXO33 has been implicated in diseases, including certain cancers, where it may act as a tumor suppressor or oncogene depending on context. For instance, FBXO33 reportedly targets histone methyltransferase SUV39H1 for degradation, influencing heterochromatin stability. The FBXO33 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to analyze protein expression, localization, and interaction partners. Its specificity is often validated using knockout controls or siRNA-mediated knockdown. Researchers employ this antibody to explore FBXO33's mechanistic roles in cellular homeostasis, disease pathways, and potential therapeutic targeting. Commercial antibodies are typically raised against conserved epitopes, enabling cross-reactivity in human, mouse, and rat models.